Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
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DOI: 10.1021/acs.jmedchem.7b01155
Abstract: Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, has emerged as an attractive target for cancer therapy. Mcl-1 upregulation is often found in many human cancers and is associated… read more here.
Keywords: potent selective; indole diazepinone; selective tricyclic; cell leukemia ... See more keywords