Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112451
Abstract: We report the design of hetero-bifunctional small molecules that selectively target p38α and p38β for degradation. These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, which is linked… read more here.
Keywords: degradation; target p38; protacs; p38 p38 ... See more keywords
Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00135
Abstract: Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its ability to form spores,… read more here.
Keywords: difficile; clostridioides difficile; selectively target; picolinamide antibacterials ... See more keywords
Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening
Sign Up to like & getrecommendations! Published in 2017 at "SLAS Discovery"
DOI: 10.1177/2472555217698942
Abstract: ARID1A, a component of the chromatin remodeling complex SWI/SNF, is an evolutionarily conserved complex that uses the energy of adenosine triphosphate hydrolysis to remodel chromatin structure and functions as a master regulator of gene transcription.… read more here.
Keywords: cell cycle; target arid1a; cell; selectively target ... See more keywords
Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12030585
Abstract: There is a pressing need to develop new antimicrobials to help combat the increase in antibiotic resistance that is occurring worldwide. In the current research, short amphiphilic antibacterial and antibiofilm agents were produced by tuning… read more here.
Keywords: anthranilamide peptidomimetic; design selectively; target planktonic; peptidomimetic design ... See more keywords