Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer
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DOI: 10.1002/iub.2524
Abstract: Cancer stem cells (CSCs) are a subgroup of cells in malignant cancers, which possess self‐renewal capacity, tumor‐initiating capability, and pluripotency, as well as being responsible for tumor maintenance, metastasis, relapse, and chemoresistance. The treatment modalities… read more here.
Keywords: cancer stem; therapeutic strategies; cancer; stem cells ... See more keywords
Selectively targeting individual bromodomain: drug discovery and molecular mechanisms.
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DOI: 10.1016/j.phrs.2021.105804
Abstract: Bromodomain-containing proteins include bromodomain and extra-terminal (BET) and non-BET families. Due to the conserved bromodomain (BD) module between BD-containing proteins, and especially BETs with each member having two BDs (BD1 and BD2), the high degree… read more here.
Keywords: drug discovery; bet; selectively targeting; bromodomain ... See more keywords