Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor
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DOI: 10.1111/bph.14080
Abstract: Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signalling by tyrosine dephosphorylation of the insulin receptor. It is a highly validated target for type 2 diabetes therapeutics. Here, the anti‐diabetic effects of HPN were evaluated… read more here.
Keywords: cell permeability; selectivity cell; tyrosine phosphatase; protein tyrosine ... See more keywords