Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation
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DOI: 10.1016/j.cell.2017.02.026
Abstract: Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO). Surprisingly, the EPO R150Q mutant… read more here.
Keywords: cytokine; functional selectivity; epo; selectivity cytokine ... See more keywords