Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells
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DOI: 10.1021/acs.jmedchem.2c00772
Abstract: G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the discovery of cytostatic immune-stimulating ligands.… read more here.
Keywords: cytotoxicity; selectivity cytotoxicity; quadruplex ligands; affinity selectivity ... See more keywords