Sodium ions do not stabilize the selectivity filter of a potassium channel.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167091
Abstract: Ion conduction is an essential function for electrical activity in all organisms. The non-selective ion channel NaK was previously shown to adopt two stable conformations of the selectivity filter. Here, we present solid-state NMR measurements… read more here.
Keywords: selective mutants; channel; sodium ions; selectivity ... See more keywords
Role of ion distribution and energy barriers for concerted motion of subunits in selectivity filter gating of a K+ channel.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167522
Abstract: Most potassium channels have two main gate locations, hosting an inner gate at the cytosolic entrance and a filter gate in the selectivity filter; the function of these gates is in many channels coupled. To… read more here.
Keywords: gate; filter gating; filter; filter gate ... See more keywords
Early Steps in C-Type Inactivation of the hERG Potassium Channel
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01028
Abstract: Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic detail of… read more here.
Keywords: potassium; type inactivation; selectivity filter; inactivation ... See more keywords
Insights into the mechanisms of K+ permeation in K+-channels from computer simulations.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.9b00971
Abstract: Ion permeation, selectivity, and the behaviour of the K+ channel selectivity filter has been studied intensively in the previous two decades. The agreement among multiple approaches used to study ion flux in K+-channels suggests a… read more here.
Keywords: permeation; insights mechanisms; occupancy; mechanisms permeation ... See more keywords
Direct Detection of Bound Ammonium Ions in the Selectivity Filter of Ion Channels by Solid-State NMR
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13247
Abstract: The flow of ions across cell membranes facilitated by ion channels is an important function for all living cells. Despite the huge amount of structural data provided by crystallography, elucidating the exact interactions between the… read more here.
Keywords: selectivity filter; selectivity; ion channels; ammonium ions ... See more keywords
Water inside the Selectivity Filter of a K+ Ion Channel: Structural Heterogeneity, Picosecond Dynamics, and Hydrogen Bonding
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c11513
Abstract: Water inside biological ion channels regulates the key properties of these proteins, such as selectivity, ion conductance, and gating. In this article, we measure the picosecond spectral diffusion of amide I vibrations of an isotope-labeled… read more here.
Keywords: selectivity filter; water; picosecond; ion ... See more keywords
Probing Ion Binding in the Selectivity Filter of the KcsA Potassium Channel.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b01092
Abstract: In potassium (K+) channels, permeation, selectivity, and gating at the selectivity filter are all governed by the thermodynamics and kinetics of the ion-protein interactions. Specific contacts between the carbonyl groups from the Thr-Val-Gly-Tyr-Gly signature filter… read more here.
Keywords: ion binding; binding sites; ion; kcsa ... See more keywords
Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13227-w
Abstract: Potassium channels are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control channel opening, closing, and inactivation. However, the molecular mechanism of how these gates regulate K+… read more here.
Keywords: channel; activation gate; potassium; selectivity filter ... See more keywords
Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48823-y
Abstract: The two-pore domain potassium (K2P) channels TREK-1 and TREK-2 link neuronal excitability to a variety of stimuli including mechanical force, lipids, temperature and phosphorylation. This regulation involves the C-terminus as a polymodal stimulus sensor and… read more here.
Keywords: filter; trek; selectivity filter; mechanism ... See more keywords
Constitutive sodium permeability in a C. elegans two-pore domain potassium channel
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2024.01.22.576648
Abstract: Two-pore domain potassium (K2P) channels play a central role in modulating cellular excitability and neuronal function. The unique structure of the selectivity filter in K2P and other potassium channels determines their ability to allow the… read more here.
Keywords: two pore; sodium; k2p; selectivity filter ... See more keywords
Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm8804
Abstract: C-type inactivation is a process by which ion flux through a voltage-gated K+ (Kv) channel is regulated at the selectivity filter. While prior studies have indicated that C-type inactivation involves structural changes at the selectivity… read more here.
Keywords: voltage gated; gated channel; type inactivation; selectivity filter ... See more keywords