Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
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DOI: 10.1038/s41467-021-23539-5
Abstract: Autophagy can selectively target protein aggregates, pathogens, and dysfunctional organelles for the lysosomal degradation. Aberrant regulation of autophagy promotes tumorigenesis, while it is far less clear whether and how tumor-specific alterations result in autophagic aberrance.… read more here.
Keywords: cancer; human cancer; autophagy selectivity; selectivity human ... See more keywords
Quantitative insights into the mechanism of proton conduction and selectivity for the human voltage-gated proton channel Hv1
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2407479121
Abstract: Significance The almost perfect proton selectivity of the human voltage-gated proton (hHv1) channels is a long-standing mystery. The extensive multiscale simulations in this paper offer quantitative insight into the mechanism behind the selective proton transport… read more here.
Keywords: proton; selectivity human; human voltage; voltage gated ... See more keywords