Plasticity in binding confers selectivity in ligand induced protein degradation
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DOI: 10.1038/s41589-018-0055-y
Abstract: Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recruitment and selectivity,… read more here.
Keywords: selectivity ligand; ligand induced; protein degradation; induced protein ... See more keywords