Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile.
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DOI: 10.1021/acsmedchemlett.1c00218
Abstract: The voltage-gated sodium channel Nav1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human genetic validation. While isoform selective molecules have been discovered and advanced into… read more here.
Keywords: selectivity profile; nav1 inhibitors; arylsulfonamide nav1; optimization ... See more keywords