Identification and selectivity profiling of small-molecule degraders via multi-omics approaches.
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DOI: 10.1016/j.chembiol.2021.03.007
Abstract: The therapeutic modality of targeted protein degradation promises to overcome limitations of traditional pharmacology. Small-molecule degraders recruit disease-causing proteins to E3 ubiquitin ligases, prompting their ubiquitination and degradation by the proteasome. The discovery, mechanistic elucidation,… read more here.
Keywords: multi omics; molecule degraders; small molecule; selectivity profiling ... See more keywords