Effects of rigidity on the selectivity of protein kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.053
Abstract: Established strategies for discovering selective kinase inhibitors are target-centric as they often target certain structural or reactive features in the target kinase. In the absence of such prominent features, there is a lack of general… read more here.
Keywords: kinase inhibitors; rigidity selectivity; kinase; effects rigidity ... See more keywords
Structure-dependent receptor subtype selectivity and G protein subtype preference of heterocyclic agonists in heterologously expressed silkworm octopamine receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2021.104895
Abstract: (R)-Octopamine (OA), a major invertebrate biogenic amine, plays an important role in a wide variety of physiological processes as a neurohormone, neuromodulator, and neurotransmitter in insects. OA receptors (OARs) are class A G protein-coupled receptors… read more here.
Keywords: subtype selectivity; dependent receptor; receptor subtype; subtype ... See more keywords
Selectivity of Protein Interactions Stimulated by Terahertz Signals
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on NanoBioscience"
DOI: 10.1109/tnb.2022.3189549
Abstract: It has been established that Terahertz (THz) band signals can interact with biomolecules through resonant modes. Specifically, of interest here, protein activation. Our research goal is to show how directing the mechanical signaling inside protein… read more here.
Keywords: system; protein interactions; selectivity; interactions stimulated ... See more keywords
Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27207065
Abstract: Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects. The selective κOR agonist nalfurafine… read more here.
Keywords: nalfurafine analogs; intracellular signaling; arrestin mediated; selectivity ... See more keywords