SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity
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DOI: 10.1158/2326-6066.cir-17-0051
Abstract: T cell–based immunotherapy against melanoma-associated antigens can result in on-target/off-tumor cytotoxicity. SLC45A2, a protein overexpressed in melanoma compared with normal melanocytes, was identified as a T-cell target that may be less prone to inducing autoimmune… read more here.
Keywords: melanoma; slc45a2; tumor selectivity; selectivity reduced ... See more keywords