Effect of selegiline as a monomine oxidase B inhibitor on the expression of neurotrophin mRNA levels in a contusion rat model of spinal cord injury
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2129761
Abstract: ABSTRACT Objective Spinal cord injury (SCI) is followed by a cascade of events at the site of injury, including vascular ischemia, an increase in free radicals, inflammation, and neuronal death. In these individuals, protection of… read more here.
Keywords: cord; cord injury; expression; spinal cord ... See more keywords
Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkaa058
Abstract: Selegiline is a selective, irreversible monoamine oxidase-B inhibitor, used for reducing symptoms in early-stage Parkinson's disease. The metabolites of selegiline include l-methamphetamine, l-amphetamine, and desmethylselegiline. The stereoisomers of selegiline metabolites, d-methamphetamine and d-amphetamine, are highly… read more here.
Keywords: methamphetamine amphetamine; selegiline; detection; selegiline metabolites ... See more keywords
Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug discovery technologies"
DOI: 10.2174/1570163815666180418144019
Abstract: Selegiline hydrochloride, a hydrophilic anti-Parkinson' moiety, undergoes extensive first-pass metabolism and has low bioavailability. A process to obtain of selegiline (SH) loaded chitosan nanoparticles was attempted to circumvent the above problem, through intranasal delivery. SH… read more here.
Keywords: loaded chitosan; chitosan nanoparticles; selegiline loaded; selegiline ... See more keywords
Efficacy and safety of selegiline for the treatment of Parkinson's disease: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1134472
Abstract: Background Drug efficacy generally varies with different durations. There is no systematic review analyzing the effect of selegiline for Parkinson's disease (PD) on different treatment duration. This study aims to analyze how the efficacy and… read more here.
Keywords: safety; parkinson disease; systematic review; efficacy ... See more keywords
Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22062853
Abstract: Age-related hearing loss (ARHL), a sensorineural hearing loss of multifactorial origin, increases its prevalence in aging societies. Besides hearing aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent… read more here.
Keywords: hearing loss; age related; age; selegiline ... See more keywords