Chemical synthesis of per‐selenocysteine human epidermal growth factor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3464
Abstract: Human seleno‐epidermal growth factor (seleno‐EGF), a 53‐residue peptide where all six cysteine residues of the parent human EGF sequence were replaced by selenocysteines, was synthesized and the oxidative folding of a polypeptide containing three diselenide… read more here.
Keywords: chemical synthesis; selenocysteine; epidermal growth; growth factor ... See more keywords
A novel weak acid activated probe for highly selective monitoring selenocysteine in living cells.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2020.121287
Abstract: Selenocysteine (Sec, pKa 5.8) is genetically encoded 21st amino acid into the active site of selenoproteins, which have broad functions relevant to various diseases, tissues or organs and subcellular organelles. However, many selenoproteins involved cellular… read more here.
Keywords: probe; sec; novel weak; acid activated ... See more keywords
Effect of Methylmercury Binding on the Peroxide-Reducing Potential of Cysteine and Selenocysteine.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c03619
Abstract: Methylmercury (CH3Hg+) binding to catalytically fundamental cysteine and selenocysteine of peroxide-reducing enzymes has long been postulated as the origin of its toxicological activity. Only very recently, CH3Hg+ binding to the selenocysteine of thioredoxin reductase has… read more here.
Keywords: cysteine selenocysteine; selenocysteine; reducing potential; methylmercury ... See more keywords
Engineering Self-Calibrating Nanoprobes with Two-Photon-Activated Fluorescence Resonance Energy Transfer for Ratiometric Imaging of Biological Selenocysteine.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b04555
Abstract: Selenocysteine (Sec) has proven to be the dominant active site of diverse selenoproteins that are directly linked with human health and disease. Thus, understanding the critical functions and dynamics of endogenous Sec at cellular and… read more here.
Keywords: photon; energy transfer; two photon; imaging biological ... See more keywords
Computational identification of the selenocysteine tRNA (tRNASec) in genomes
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005383
Abstract: Selenocysteine (Sec) is known as the 21st amino acid, a cysteine analogue with selenium replacing sulphur. Sec is inserted co-translationally in a small fraction of proteins called selenoproteins. In selenoprotein genes, the Sec specific tRNA… read more here.
Keywords: trna trnasec; sec; biology; selenocysteine ... See more keywords
Species-Specific, pH-Independent, Standard Redox Potential of Selenocysteine and Selenocysteamine
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9060465
Abstract: Microscopic redox equilibrium constants and standard redox potential values were determined to quantify selenolate-diselenide equilibria of biological significance. The highly composite, codependent acid-base and redox equilibria of selenolates could so far be converted into pH-dependent,… read more here.
Keywords: equilibrium constants; standard redox; redox potential; redox ... See more keywords
Determination of Proteinaceous Selenocysteine in Selenized Yeast
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19020543
Abstract: A method for the quantitation of proteinaceous selenocysteine (SeCys) in Se-rich yeast was developed. The method is based on the reduction of the Se-Se and S-Se bridges with dithiotretiol, derivatization with iodoacetamide (carbamidomethylation), followed by… read more here.
Keywords: determination proteinaceous; selenocysteine selenized; selenocysteine; selenium ... See more keywords