Stereoselective α-Deuteration of Serine, Cysteine, Selenocysteine, and 2,3-Diaminopropanoic Acid Derivatives.
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DOI: 10.1021/acs.orglett.2c02715
Abstract: Efficient methodologies for synthesizing enantiopure α-deuterated derivatives of serine, cysteine, selenocysteine, and 2,3-diaminopropanoic acid have been developed. H/D exchange was achieved by deprotonation of a chiral bicyclic serine equivalent followed by selective deuteration. Additionally, diastereoselective… read more here.
Keywords: selenocysteine diaminopropanoic; cysteine selenocysteine; diaminopropanoic acid;