Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12558
Abstract: Peptide ligation chemistry has revolutionized protein science by providing access to homogeneously modified peptides and proteins. However, lipidated polypeptides and integral membrane proteins - an important class of biomolecules - remain enormously challenging to access… read more here.
Keywords: reductive diselenide; peptide ligation; ligation; diselenide selenoester ... See more keywords
Generation of oligonucleotide conjugates via one-pot diselenide-selenoester ligation–deselenization/alkylation
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc04937b
Abstract: A breadth of strategies are needed to efficiently modify oligonucleotides with peptides or lipids to capitalize on their therapeutic and diagnostic potential, including the modulation of in vivo chemical stability and for applications in cell-targeting… read more here.
Keywords: oligonucleotide conjugates; deselenization; diselenide; diselenide selenoester ... See more keywords