Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors.
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DOI: 10.1016/j.ejmech.2020.112716
Abstract: A series of novel vinyl selenone derivatives were designed, synthesized and evaluated as the tubulin polymerization inhibitors using a bioisosteric strategy. Among them, the representative compound 11k exhibited satisfactory anti-proliferative activities with IC50 values ranging… read more here.
Keywords: polymerization; polymerization inhibitors; microtubule polymerization; selenone derivatives ... See more keywords