BEESEM: estimation of binding energy models using HT‐SELEX data
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx191
Abstract: Motivation: Characterizing the binding specificities of transcription factors (TFs) is crucial to the study of gene expression regulation. Recently developed high‐throughput experimental methods, including protein binding microarrays (PBM) and high‐throughput SELEX (HT‐SELEX), have enabled rapid… read more here.
Keywords: beesem estimation; using selex; data beesem; beesem ... See more keywords
Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad318
Abstract: Homeodomain proteins constitute one of the largest families of metazoan transcription factors. Genetic studies have demonstrated that homeodomain proteins regulate many developmental processes. Yet, biochemical data reveal that most bind highly similar DNA sequences. Defining… read more here.
Keywords: selex data; homeodomain; dna binding; high throughput ... See more keywords