Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.11.015
Abstract: Abstract Cu(II) phenanthroline complexes are able to cleave DNA and show cytotoxic activity against cancer cells. Also, the biological activity of hydrazone-based compounds has been reported in the literature. This motivated us to combine these… read more here.
Keywords: complexes hydrazone; functionalized phenanthrolines; self activating; hydrazone functionalized ... See more keywords
A self-activating orphan receptor
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DOI: 10.1038/d41586-020-00411-y
Abstract: The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering therapeutics. The structure of an… read more here.
Keywords: receptor; self activating; activating orphan; orphan receptor ... See more keywords
Structure determines function—the role of topology in the functionality of gene circuits
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Biology"
DOI: 10.1093/synbio/ysaa008
Abstract: As synthetic biologists, we sometimes forget the toggle switch and the self-activating switch, the foundational advances that launched the entire field of synthetic biology a mere two decades ago. As the first in a long… read more here.
Keywords: self activating; topology; circuit; biology ... See more keywords