Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA
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DOI: 10.1021/jacs.8b13298
Abstract: Molecular evolution can be conceptualized as a walk over a “fitness landscape”, or the function of fitness (e.g., catalytic activity) over the space of all possible sequences. Understanding evolution requires knowing the structure of the… read more here.
Keywords: self aminoacylating; ribozyme; landscape; fitness landscape ... See more keywords
Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness
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DOI: 10.1038/s41467-024-52362-x
Abstract: Modern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed… read more here.
Keywords: self aminoacylating; rna world; amino acids; rna ... See more keywords