Laccase-Based Self-Amplifying Catalytic System Enables Efficient Antibiotic Degradation for Sustainable Environmental Remediation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300210
Abstract: Antibiotic contamination poses potential risks to ecosystems and human health. Laccase (LAC) has emerged as a promising biocatalyst for the oxidation of environmentally toxic contaminants with high catalytic efficiency; however, its large-scale application is hindered… read more here.
Keywords: self amplifying; amplifying catalytic; catalytic system; remediation ... See more keywords
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2021.113900
Abstract: The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA (saRNA) as a flexible immunotherapy platform to treat infectious diseases. Besides the… read more here.
Keywords: amplifying mrna; self amplifying; innate immune; activity ... See more keywords
Biomass burning related ammonia emissions promoted a self-amplifying loop in the urban environment in Kunming (SW China)
Sign Up to like & getrecommendations! Published in 2020 at "Atmospheric Environment"
DOI: 10.1016/j.atmosenv.2020.118138
Abstract: Abstract Particulate ammonium (NH4+) is one of the most important inorganic components in aerosol. The concentrations of NH4+ in PM2.5 significantly increased when PM2.5 levels elevated. Increased understanding of the atmospheric processes and sources of… read more here.
Keywords: biomass burning; environment; self amplifying; burning related ... See more keywords
Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.11.040
Abstract: Nucleic acid vaccines represent an attractive approach to vaccination, combining the positive attributes of both viral vectors and live-attenuated vaccines, without the inherent limitations of each technology. We have developed a novel technology, the Self-Amplifying… read more here.
Keywords: sam vaccines; amplifying mrna; bacterial antigens; immunogenicity ... See more keywords
Self-Amplifying Assembly of Peptides in Macrophages for Enhanced Inflammatory Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01323
Abstract: Enzyme-regulated in situ self-assembly of peptides represents one versatile strategy in the creation of theranostic agents, which, however, is limited by the strong dependence on enzyme overexpression. Herein, we reported the self-amplifying assembly of peptides… read more here.
Keywords: assembly peptides; self amplifying; amplifying assembling; amplifying assembly ... See more keywords
Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b07705
Abstract: We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives… read more here.
Keywords: generating self; self amplifying; triggered acid; acid generating ... See more keywords
A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale horizons"
DOI: 10.1039/d1nh00506e
Abstract: Ferroptosis, an unusual non-apoptotic cell death caused by the iron-dependent accumulation of lipid peroxide, enables the flexible design of an antitumor platform. Specifically, as a positive role, ferroptosis can induce an immune response accompanied with… read more here.
Keywords: self amplifying; nature ferroptosis; janus faced; faced nature ... See more keywords
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Human Gene Therapy"
DOI: 10.1089/hum.2017.121
Abstract: Among nucleic acid–based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify intracellularly,… read more here.
Keywords: self amplifying; virus immune; vaccinia; expression ... See more keywords
Development of a potent Zika virus vaccine using self-amplifying messenger RNA
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba5068
Abstract: A Zika self-amplifying mRNA vaccine delivered by a flexible bedside mixing formulation induces protective immunity in NHPs. Zika virus (ZIKV) is the cause of a pandemic associated with microcephaly in newborns and Guillain-Barre syndrome in… read more here.
Keywords: self amplifying; vaccine; using self; amplifying messenger ... See more keywords
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abn3464
Abstract: As mRNA vaccines have proved to be very successful in battling the coronavirus disease 2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the development of potent vaccines against other infectious diseases and… read more here.
Keywords: self amplifying; replicating mrna; mrna vaccines; hpv ... See more keywords
Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041173
Abstract: Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines. The COVID-19 pandemic was a stark reminder of Africa’s… read more here.
Keywords: self amplifying; permanently cationic; cationic ionizable; delivery ... See more keywords