Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity
Sign Up to like & getrecommendations! Published in 2025 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.70036
Abstract: Self‐amplifying RNA (saRNA) vectors have garnered significant attention for their potential in transient recombinant protein expression and vaccination strategies. These vectors are notable for their safety and the ability to produce high levels of protein… read more here.
Keywords: self amplifying; sarna vectors; amplifying rna; expression ... See more keywords
Laccase-Based Self-Amplifying Catalytic System Enables Efficient Antibiotic Degradation for Sustainable Environmental Remediation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300210
Abstract: Antibiotic contamination poses potential risks to ecosystems and human health. Laccase (LAC) has emerged as a promising biocatalyst for the oxidation of environmentally toxic contaminants with high catalytic efficiency; however, its large-scale application is hindered… read more here.
Keywords: self amplifying; amplifying catalytic; catalytic system; remediation ... See more keywords
Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202409506
Abstract: Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor‐specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ‐H2 is designed that can… read more here.
Keywords: vivo; tumor; self amplifying; chemical transformation ... See more keywords
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2021.113900
Abstract: The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA (saRNA) as a flexible immunotherapy platform to treat infectious diseases. Besides the… read more here.
Keywords: amplifying mrna; self amplifying; innate immune; activity ... See more keywords
Biomass burning related ammonia emissions promoted a self-amplifying loop in the urban environment in Kunming (SW China)
Sign Up to like & getrecommendations! Published in 2020 at "Atmospheric Environment"
DOI: 10.1016/j.atmosenv.2020.118138
Abstract: Abstract Particulate ammonium (NH4+) is one of the most important inorganic components in aerosol. The concentrations of NH4+ in PM2.5 significantly increased when PM2.5 levels elevated. Increased understanding of the atmospheric processes and sources of… read more here.
Keywords: biomass burning; environment; self amplifying; burning related ... See more keywords
Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.11.040
Abstract: Nucleic acid vaccines represent an attractive approach to vaccination, combining the positive attributes of both viral vectors and live-attenuated vaccines, without the inherent limitations of each technology. We have developed a novel technology, the Self-Amplifying… read more here.
Keywords: sam vaccines; amplifying mrna; bacterial antigens; immunogenicity ... See more keywords
Spatiotemporally Ultrasound-Activatable Self-Amplifying Biomimetic Liposomes for Imaging-Guided Synergistic Cancer Sonodynamic Chemotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Nano letters"
DOI: 10.1021/acs.nanolett.5c03350
Abstract: Overcoming hypoxia and enhancing therapeutic precision remain critical challenges for sonodynamic therapy (SDT) in oncology. Herein, we develop a biomimetic liposomal platform (DiR-VT@cmLipo) coencapsulating the sonosensitizer verteporfin (VP) and hypoxia-activated prodrug evofosfamide (TH302), which synergistically… read more here.
Keywords: sonodynamic chemotherapy; self amplifying; imaging guided; tumor ... See more keywords
Self-Amplifying Assembly of Peptides in Macrophages for Enhanced Inflammatory Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01323
Abstract: Enzyme-regulated in situ self-assembly of peptides represents one versatile strategy in the creation of theranostic agents, which, however, is limited by the strong dependence on enzyme overexpression. Herein, we reported the self-amplifying assembly of peptides… read more here.
Keywords: assembly peptides; self amplifying; amplifying assembling; amplifying assembly ... See more keywords
Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b07705
Abstract: We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives… read more here.
Keywords: generating self; self amplifying; triggered acid; acid generating ... See more keywords
A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01251-5
Abstract: Pseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity.… read more here.
Keywords: self amplifying; immunity; sarna vaccine; prv sarna ... See more keywords
An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial
Sign Up to like & getrecommendations! Published in 2024 at "Nature Medicine"
DOI: 10.1038/s41591-024-02955-2
Abstract: Here we conducted a multicenter open-label, randomized phase 2 and 3 study to assess the safety and immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron-specific (BA.1/B.1.1.529), monovalent, thermostable, self-amplifying mRNA vaccine, GEMCOVAC-OM,… read more here.
Keywords: self amplifying; amplifying mrna; vaccine; phase ... See more keywords