Suppression of Autoimmune Rheumatoid Arthritis with Hybrid Nanoparticles That Induce B and T Cell Tolerance to Self-Antigen.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c05643
Abstract: Autoimmune diseases affect over 4% of the world's population. Treatments are generally palliative or use broad spectrum immunosuppressants to reduce symptoms and disease progression. In some diseases, antibodies generated to a single autoantigen are the… read more here.
Keywords: cell; rheumatoid arthritis; self antigen; tolerance ... See more keywords
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm0817-1004a
Abstract: Nat. Med. 22, 1482–1487 (2016); published online 31 October 2016; corrected after print 18 April 2017 In the version of this article initially published, the IA-2545–562 peptide identified as a target of a T cell… read more here.
Keywords: antigen specificity; specificity islet; islet infiltrating; self antigen ... See more keywords
Association of early-onset Alzheimer’s disease with germline-generated high affinity self-antigen load
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-0826-6
Abstract: Self-antigen presentation outside the central nervous system has crucial role regarding self-proteins tolerance and autoimmunity, leading to neuroinflammation. Self-antigen with strong-binding affinity is considered to be pathogenic. We aim to investigate whether strong-binding affinity self-antigen… read more here.
Keywords: onset; antigen load; affinity self; self antigen ... See more keywords
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07603-1
Abstract: Tumours often evade CD8 T-cell immunity by downregulating TAP. T-cell epitopes associated with impaired peptide processing are immunogenic non-mutated neoantigens that emerge during tumour immune evasion. The preprocalcitonin (ppCT)16–25 neoepitope belongs to this category of… read more here.
Keywords: cell responses; peptide; responses toward; antigen ... See more keywords
B‐cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13062
Abstract: The random recombination of immunoglobulin V(D)J gene segments produces unique IgM antibodies that serve as the antigen receptor for each developing B cell. Hence, the newly formed B cell repertoire is comprised of a variety… read more here.
Keywords: cell; self antigen; mouse human; central tolerance ... See more keywords
Cyclophosphamide eradicates murine immunogenic tumor coding for a non-self-antigen and induces antitumor immunity
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/2058738418796591
Abstract: Although the majority of cancers respond to chemotherapy, most cancer types relapse, at least in part, due to the poor immunogenicity of most tumor. We have reported before that treatment of tumor bearing mice with… read more here.
Keywords: immunogenic tumor; non self; self antigen; mice ... See more keywords
The cathelicidin protein CRAMP is a potential atherosclerosis self-antigen in ApoE(-/-) mice
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187432
Abstract: Auto-immunity is believed to contribute to inflammation in atherosclerosis. The antimicrobial peptide LL-37, a fragment of the cathelicidin protein precursor hCAP18, was previously identified as an autoantigen in psoriasis. Given the reported link between psoriasis… read more here.
Keywords: cathelicidin protein; atherosclerosis; self antigen; apoe mice ... See more keywords