Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110384
Abstract: Impaired production of thymic regulatory T cells (Tregs) is implicated in the development of Aire-dependent autoimmunity. Because Tregs require agonistic T cell receptor stimuli by self-antigens to develop, reduced expression of self-antigens from medullary thymic epithelial cells… read more here.
Keywords: autoimmunity; self antigens; ctla expression; aire ... See more keywords
Lung Transplant Candidates With Pretransplant Gastroesophageal Reflux and Antibodies to Lung Self-antigens Have Shorter CLAD-free Survival After Transplant
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DOI: 10.1097/txd.0000000000001294
Abstract: Background. Pre–lung transplant (LTx) gastroesophageal reflux (GER) and circulating antibodies against the lung self-antigens (SAbs) collagen V and K-alpha-1 tubulin may predispose recipients to chronic lung allograft dysfunction (CLAD). We aimed to study the association… read more here.
Keywords: ltx; self antigens; lung; group ... See more keywords
Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules
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DOI: 10.1126/sciadv.abj9867
Abstract: Specific MHC class II alleles are strongly associated with susceptibility to various autoimmune diseases. Although the primary function of MHC class II molecules is to present peptides to helper T cells, MHC class II molecules… read more here.
Keywords: mhc class; class molecules; class; complexed mhc ... See more keywords
Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes
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DOI: 10.3390/ijms23063155
Abstract: While progress has been made toward understanding mechanisms that lead to the development of autoimmunity, there is less knowledge regarding protective mechanisms from developing such diseases. For example, in type 1 diabetes (T1D), the immune-mediated… read more here.
Keywords: type diabetes; targeted regulatory; regulatory cells; self antigens ... See more keywords