Zinc-Based ROS Amplifiers Trigger Cancer Chemodynamic/Ion Interference Therapy Through Self-Cascade Catalysis.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202402320
Abstract: Nanozyme-mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H2O2) levels in the tumor microenvironment (TME) poses… read more here.
Keywords: therapy; self cascade; ion interference; zno2 ... See more keywords
Light-Driven Self-Cascade Peroxidase-like Nanozymes without Exogenous H2O2.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00627
Abstract: The peroxidase (POD)-like nanozyme typically requires the addition of exogenous H2O2. To address the limitation, previous work mainly adopted a cascade strategy for H2O2 production. Herein, we propose a new light-driven self-cascade strategy to construct… read more here.
Keywords: exogenous h2o2; like nanozymes; h2o2; self cascade ... See more keywords
Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio-enzymatic Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c07691
Abstract: Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites, have shown tremendous potential as enzyme-based drugs for enzymatic therapy. However, using SAzymes in tumor theranostics remains challenging because of deficient enzymatic activity and… read more here.
Keywords: atom; enzymatic therapy; self cascade; fen4 sazyme ... See more keywords