Malt1 self‐cleavage is critical for regulatory T cell homeostasis and anti‐tumor immunity in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847597
Abstract: Mucosa‐associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF‐κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease… read more here.
Keywords: cleavage; anti tumor; malt1 self; self cleavage ... See more keywords
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117116
Abstract: AIMS LexA protein is a transcriptional repressor which regulates the expression of more than 60 genes belonging to the SOS global regulatory network activated by damages to bacterial DNA. Considering its role in bacteria, LexA… read more here.
Keywords: transcriptional repressor; inhibition; lexa self; resistance ... See more keywords
Improving the Activity and Stability of Serine Protease ThAPT3 by Alleviating Self-Cleavage and Its Application in Deproteinization of Shrimp Shells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01618
Abstract: The self-cleavage properties of proteases result in low activity and instability, which limit their industrial application. In this study, the serine protease ThAPT3 from Torrubiella hemipterigena was successfully expressed in Komagataella phaffii. We investigated the… read more here.
Keywords: application; serine protease; thapt3; self cleavage ... See more keywords
Pressure modulates the self-cleavage step of the hairpin ribozyme
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14661
Abstract: The ability of certain RNAs, denoted as ribozymes, to not only store genetic information but also catalyse chemical reactions gave support to the RNA world hypothesis as a putative step in the development of early… read more here.
Keywords: cleavage step; step; hairpin ribozyme; self cleavage ... See more keywords
Life on Minerals: Binding Behaviors of Oligonucleotides on Zirconium Silicate and Its Inhibitory Activity for the Self-Cleavage of Hammerhead Ribozyme
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111689
Abstract: The role of minerals in the chemical evolution of RNA molecules is an important issue when considering the early stage of the Hadean Earth. In particular, the interaction between functional ribozymes and ancient minerals under… read more here.
Keywords: chemical evolution; zirconium; zirconium silicate; rna ... See more keywords