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Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage

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1 Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx001

Abstract: Abstract Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3… read more here.

Keywords: dna damage; apobec3a; dna; self cytoplasmic ... See more keywords