Drug Self‐Delivery Systems: Molecule Design, Construction Strategy, and Biological Application
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DOI: 10.1002/adhm.202202769
Abstract: Drug self‐delivery systems (DSDSs) offer new ways to create novel drug delivery systems (DDSs). In typical DSDSs, therapeutic reagents are not considered passive cargos but active delivery agents of actionable targets. As an advanced drug… read more here.
Keywords: drug self; dsdss; delivery systems; self delivery ... See more keywords
Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205694
Abstract: Photodynamic therapy (PDT) can generate reactive oxygen species (ROS) to cause cell apoptosis and induce immunogenic cell death (ICD) to activate immune response, becoming a promising antitumor modality. However, the overexpressions of indoleamine 2,3-dioxygenase (IDO)… read more here.
Keywords: self delivery; tumor; photodynamic immunotherapy; immune activation ... See more keywords
A cleavable self-delivery nanoparticle for tumor photo-immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2021.01.001
Abstract: Immunotherapy of tumor attracts great attention in the past several years attributing to the potential of completely erasing primary tumor and metastasis. Therefore, pharmaceutical companies developed many antibodies that act as immune check point blockade… read more here.
Keywords: immunotherapy; delivery nanoparticle; self delivery; photo immunotherapy ... See more keywords
Self-Delivery Ternary Bioregulators for Photodynamic Amplified Immunotherapy by Tumor Microenvironment Reprogramming.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c08978
Abstract: Abnormal metabolism of cancer cells results in complex tumor microenvironments (TME), which play a dominant role in tumor metastasis. Herein, self-delivery ternary bioregulators (designated as TerBio) are constructed for photodynamic amplified immunotherapy against colorectal cancer… read more here.
Keywords: tumor; amplified immunotherapy; self delivery; delivery ternary ... See more keywords
Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02318g
Abstract: A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system… read more here.
Keywords: chemotherapy sensitized; photodynamic therapy; sensitized photodynamic; delivery nanomedicine ... See more keywords
A self-delivery photodynamic sensitizer for enhanced DNA damage by PARP inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01320g
Abstract: Tumor cells activate DNA repair pathways to combat the oxidative damage induced by reactive oxygen species (ROS), contributing to their resistance to photodynamic therapy (PDT). Herein, a self-delivery photodynamic sensitizer is developed to enhance oxidative… read more here.
Keywords: damage; photodynamic sensitizer; self delivery; tumor ... See more keywords