cGAS in action: Expanding roles in immunity and inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aat8657
Abstract: cGAS sensing of DNA: A comprehensive look The immune system uses the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) signaling pathway to detect the presence of intracellular DNA. This is beneficial because cytosolic DNA is… read more here.
Keywords: innate; cgas; dna; self dna ... See more keywords
BAF restricts cGAS on nuclear DNA to prevent innate immune activation
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aaw6421
Abstract: A loose BAF puts its foot on the cGAS A signaling pathway in vertebrates called cGAS-STING detects the presence of intracellular DNA as a surrogate for both cellular damage and viral infection. At the same… read more here.
Keywords: cgas; dna; baf; self dna ... See more keywords
Self-DNA Early Exposure in Cultivated and Weedy Setaria Triggers ROS Degradation Signaling Pathways and Root Growth Inhibition
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DOI: 10.3390/plants12061288
Abstract: The accumulation of fragmented extracellular DNA reduces conspecific seed germination and plantlet growth in a concentration-dependent manner. This self-DNA inhibition was repeatedly reported, but the underlying mechanisms are not fully clarified. We investigated the species-specificity… read more here.
Keywords: self dna; inhibition; dna; ros degradation ... See more keywords