Designer Solid Self-Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512139
Abstract: Peptide-based cancer vaccines offer favorable safety and stability profiles but are limited by rapid clearance and poor immunogenicity. Here, a ≈20 nm solid self-emulsifying (SSE) nanovaccine platform that co-delivers peptide antigens and an oligonucleotide adjuvant containing… read more here.
Keywords: designer solid; cells cells; dendritic cells; solid self ... See more keywords
Characterization of Self-Emulsifying Drug Delivery Systems Using In Situ Raman Spectroscopy to Study the Precipitation Inhibition Mechanism of Poorly Water-Soluble Drugs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-018-9315-3
Abstract: PurposeThe goal of this research was to study the molecular interactions in situ between actives and surfactants in self-emulsifying delivery systems (SEDDS) in order to illuminate the factor(s) and how they influence the drug performance… read more here.
Keywords: self emulsifying; precipitation; delivery systems; drug ... See more keywords
Drug supersaturation during formulation digestion, including real-time analytical approaches.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2018.11.003
Abstract: Self-emulsifying and other lipid-based drug delivery systems have drawn considerable interest from pharmaceutical scientists for managing oral delivery of poorly water-soluble compounds. Following administration, self-emulsifying systems exhibit complex aqueous dispersion and digestion in the gastro-intestinal… read more here.
Keywords: drug supersaturation; self emulsifying; lipid based; digestion ... See more keywords
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.019
Abstract: AIM The aim of this study was the formation and characterization of various ion pairs of therapeutic peptides with different surfactants in order to reach a high payload in self-emulsifying drug delivering systems (SEDDS). METHODS… read more here.
Keywords: self emulsifying; zeta potential; hydrophobic ion; drug ... See more keywords
A novel solid self-emulsifying delivery system (SEDS) for the encapsulation of linseed oil and quercetin: Preparation and evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Food Engineering"
DOI: 10.1016/j.jfoodeng.2018.01.017
Abstract: Abstract The aim of current research was to develop a solid self-emulsifying delivery system (SEDS) to enhance the delivery of linseed oil and quercetin. The pseudo ternary phase diagram was constructed to optimize the suitable… read more here.
Keywords: self emulsifying; oil quercetin; linseed oil; solid self ... See more keywords
Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine
Sign Up to like & getrecommendations! Published in 2021 at "Langmuir"
DOI: 10.1021/acs.langmuir.1c01689
Abstract: Self-emulsifying drug-delivery systems (SEDDS) have been extensively shown to increase oral absorption of solvation-limited compounds. However, there has been little clinical and commercial use of these formulations, in large part because the demonstrated advantages of… read more here.
Keywords: absorption; self emulsifying; drug delivery; emulsifying drug ... See more keywords
Enhanced Bioavailability and Pharmacokinetics of a Natural Self-Emulsifying Reversible Hybrid-Hydrogel System of Quercetin: A Randomized Double-Blinded Comparative Crossover Study
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05929
Abstract: Despite the vast array of health beneficial pharmacological effects, the bioavailability of the dietary flavonoid quercetin was found to be poor due to insolubility, incompatibility, and rapid biotransformation. Herein, we investigated the solubility, morphology, particle… read more here.
Keywords: self emulsifying; natural self; bioavailability; hybrid hydrogel ... See more keywords
Antifungal Efficacy of a Thiazolyl Hydrazone Derivative Incorporated into a Self-Emulsifying Drug Delivery System in a Murine Model of Cryptococcosis
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c02705
Abstract: 2-[2-(Cyclohexylmethylene)hydrazinyl]-4-phenylthiazole (RN104) has shown notable antifungal activity against Cryptococcus species and low toxicity. This study aimed to assess the antifungal efficacy and survival benefits of RN104 incorporated into a self-emulsifying drug delivery system (SEDDS-RN104) compared… read more here.
Keywords: self emulsifying; incorporated self; antifungal efficacy; sedds rn104 ... See more keywords
A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2110450119
Abstract: Significance Parkinson’s disease (PD) is a progressive disorder of the central nervous system that affects motor control. While subcutaneous injection of apomorphine (Apokyn) is clinically used to alleviate intermittent episodes of dyskinesia, the treatment requires… read more here.
Keywords: system; eutectic based; deep eutectic; self emulsifying ... See more keywords
Preparation and characterisation of self-emulsifying drug delivery system (SEDDS) for enhancing oral bioavailability of metformin hydrochloride using hydrophobic ion pairing complexation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2023.2170488
Abstract: Abstract Aim The aim of this study was preparation of a self-emulsifying drug delivery system (SEEDS) containing metformin hydrochloride. Methods Hydrophobic ion paired complexes were prepared by electrostatic interaction between metformin and sodium lauryl sulphate… read more here.
Keywords: self emulsifying; delivery system; emulsifying drug; drug delivery ... See more keywords
Self-emulsifying drug delivery system for enhanced solubility of asenapine maleate: design, characterization, in vitro, ex vivo and in vivo appraisal
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2019.1567758
Abstract: Abstract Self-emulsifying drug delivery systems (SES) were developed to improve oral bioavailability of asenapine maleate (ASM), an antipsychotic drug with challenging amphiphobic nature and extensive pre-systemic metabolism. ASM-SES was prepared by choosing the proportion of… read more here.
Keywords: self emulsifying; vitro vivo; vivo; emulsifying drug ... See more keywords