Recent Advancements on Self-Immolative System Based on Dynamic Covalent Bonds for Delivering Heterogeneous Payloads.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300138
Abstract: The precisely spatial-temporal delivery of heterogeneous payloads from a single system with the same pulse is in great demand in realizing versatile and synergistic functions. Very few molecular architectures can satisfy the strict requirements of… read more here.
Keywords: dynamic covalent; heterogeneous payloads; covalent bonds; drug ... See more keywords
Advanced Pyrrolidine‐Carbamate Self‐Immolative Spacer with Tertiary Amine Handle Induces Superfast Cyclative Drug Release
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200279
Abstract: Amine‐carbamate self‐immolative (SI) spacers represent practical and versatile tools in targeted prodrugs, but their slow degradation mechanism limits drug activation at the site of disease. We engineered a pyrrolidine‐carbamate SI spacer with a tertiary amine… read more here.
Keywords: pyrrolidine carbamate; self immolative; spacer; spacer tertiary ... See more keywords
Hypoxia Activated Fluorescent Probe Based on Self-immolative Block Copolymer.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100417
Abstract: This work reported a hypoxia activated fluorescent probe for tumor imaging by using self-immolative block copolymer with azobenzene linkage. The water-soluble polymer composed of self-immolative building blocks showed no obvious fluorescence. Under the hypoxic microenvironment… read more here.
Keywords: activated fluorescent; block copolymer; immolative block; fluorescent probe ... See more keywords
A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c02381
Abstract: Existing tools to detect and visualize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suffer from low selectivity, poor cell permeability, and high cytotoxicity. Here we report a novel self-immolative fluorescent probe (MP590) for the highly… read more here.
Keywords: detection; self immolative; sars cov; fluorescent probe ... See more keywords
Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00239
Abstract: The reversible addition–fragmentation chain-transfer (RAFT) polymerization provides access to a broad variety of biocompatible and functional macromolecules for diverse polymer–drug conjugates. Due to thiocarbonylthio groups at the ends of each growing polymer chain, they can… read more here.
Keywords: polymer drug; raft; end; drug ... See more keywords
Synthesis and Closed-Loop Recycling of Self-Immolative Poly(dithiothreitol)
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecules"
DOI: 10.1021/acs.macromol.0c00861
Abstract: Self-immolative polymers (SIPs) are promising members of the emerging class of recyclable polymers with the ability to end-to-end depolymerize to their monomers. Unfortunately, SIPs are often synth... read more here.
Keywords: recycling self; synthesis closed; loop recycling; self immolative ... See more keywords
Polyglyoxylamides: Tuning Structure and Properties of Self-Immolative Polymers
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecules"
DOI: 10.1021/acs.macromol.8b02616
Abstract: Self-immolative polymers (SIPs) are a class of stimuli-responsive materials that undergo controlled end-to-end depolymerization in response to stimuli. Their unique degradation and amplification properties have made them of interest for a diverse array of applications… read more here.
Keywords: tuning structure; properties self; polyglyoxylamides tuning; immolative polymers ... See more keywords
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03299
Abstract: A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promotes fragmentation even… read more here.
Keywords: grob fragmentation; self immolative; based grob; fragmentation ... See more keywords
Synthesis of End-Cap Enabled Self-Immolative Photoresists For Extreme Ultraviolet Lithography.
Sign Up to like & getrecommendations! Published in 2022 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00395
Abstract: Conventional chemically amplified resists (CARs) rely on the usage of photoacid generators to serve as the source of chemical amplification. However, acid diffusion inevitably accompanies CARs and has led to the resolution, line edge roughness,… read more here.
Keywords: lithography; extreme ultraviolet; cap enabled; cap ... See more keywords
Oxidation Responsive Polymers with a Triggered Degradation via Arylboronate Self-Immolative Motifs on a Polyphosphazene Backbone
Sign Up to like & getrecommendations! Published in 2017 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.7b00015
Abstract: Oxidation responsive polymers with triggered degradation pathways have been prepared via attachment of self-immolative moieties onto a hydrolytically unstable polyphosphazene backbone. After controlled main-chain growth, postpolymerization functionalization allows the preparation of hydrolytically stable poly(organo)phosphazenes decorated… read more here.
Keywords: responsive polymers; degradation; triggered degradation; polymers triggered ... See more keywords
Self-Immolative Polymers: An Emerging Class of Degradable Materials with Distinct Disassembly Profiles
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11410
Abstract: Self-immolative polymers are an emerging class of macromolecules with distinct disassembly profiles that set them apart from other general degradable materials. These polymers are programmed to disassemble spontaneously from head to tail, through a domino-like… read more here.
Keywords: emerging class; degradable materials; immolative polymers; self immolative ... See more keywords