Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202513250
Abstract: Conventional “always‐on” photosensitizers are often plagued by off‐target toxicity and poor tumor selectivity, limiting the clinical efficacy of photodynamic therapy (PDT). Herein, an innovative quinone methide (QM)‐gated self‐immolative ‘OFF‐ON’ nano‐photosensitizer platform (Pyz/PS) is reported for… read more here.
Keywords: self immolative; immolative activatable; activatable nanoassembly; photodynamic therapy ... See more keywords
Recent Advancements on Self-Immolative System Based on Dynamic Covalent Bonds for Delivering Heterogeneous Payloads.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300138
Abstract: The precisely spatial-temporal delivery of heterogeneous payloads from a single system with the same pulse is in great demand in realizing versatile and synergistic functions. Very few molecular architectures can satisfy the strict requirements of… read more here.
Keywords: dynamic covalent; heterogeneous payloads; covalent bonds; drug ... See more keywords
Design and Evaluation of Biodegradable Self‐Immolative Lipids for RNA Delivery
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501305
Abstract: Lipid nanoparticle (LNP) is a proven platform for the safe and efficacious delivery of nucleic acid‐based therapeutics. Regulatory approvals of Patisiran, and mRNA vaccines against Covid‐19 are testaments to this fact. A key requisite for… read more here.
Keywords: self immolative; biodegradable self; delivery; immolative lipids ... See more keywords
An Enzyme‐Responsive Self‐Immolative Recognition Marker for Manipulating Cell–Cell Interactions (Adv. Sci. 36/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470221
Abstract: Living Sells as Chemicals Cell‐cell interactions can be manipulated ‘on demand’ using self‐responsive chemical tools. In the article number 2402278, Sébastien Papot and his colleagues show that enzyme‐sensitive cell surface markers enable the formation and… read more here.
Keywords: cell cell; responsive self; self immolative; cell interactions ... See more keywords
Hydrophobic Domain Modulation of Chemical Responsiveness in a Bolaamphiphile‐Based Supramolecular Monomer
Sign Up to like & getrecommendations! Published in 2024 at "Chembiochem"
DOI: 10.1002/cbic.202400348
Abstract: Self‐immolative chemistries that respond in an irreversible manner to external stimuli are highly attractive to permanently degrade filamentous supramolecular biomaterials. Within the monomer, a balance needs to be struck between its capacity to be supramolecularly… read more here.
Keywords: self immolative; chemical; supramolecular polymers; hydrophobic domain ... See more keywords
Advanced Pyrrolidine‐Carbamate Self‐Immolative Spacer with Tertiary Amine Handle Induces Superfast Cyclative Drug Release
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200279
Abstract: Amine‐carbamate self‐immolative (SI) spacers represent practical and versatile tools in targeted prodrugs, but their slow degradation mechanism limits drug activation at the site of disease. We engineered a pyrrolidine‐carbamate SI spacer with a tertiary amine… read more here.
Keywords: pyrrolidine carbamate; self immolative; spacer; spacer tertiary ... See more keywords
Hypoxia Activated Fluorescent Probe Based on Self-immolative Block Copolymer.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100417
Abstract: This work reported a hypoxia activated fluorescent probe for tumor imaging by using self-immolative block copolymer with azobenzene linkage. The water-soluble polymer composed of self-immolative building blocks showed no obvious fluorescence. Under the hypoxic microenvironment… read more here.
Keywords: activated fluorescent; block copolymer; immolative block; fluorescent probe ... See more keywords
A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c02381
Abstract: Existing tools to detect and visualize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suffer from low selectivity, poor cell permeability, and high cytotoxicity. Here we report a novel self-immolative fluorescent probe (MP590) for the highly… read more here.
Keywords: detection; self immolative; sars cov; fluorescent probe ... See more keywords
Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.
Sign Up to like & getrecommendations! Published in 2024 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.4c00376
Abstract: Prodrug-type oligonucleotides (prodrug-ONs) are a class of oligonucleotide designed for activation under specific intracellular conditions or external stimuli. Prodrug-ONs can be activated in the target tissues or cells, thereby reducing the risk of adverse effects.… read more here.
Keywords: self immolative; prodrug type; linker; type oligodeoxynucleotides ... See more keywords
Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00239
Abstract: The reversible addition–fragmentation chain-transfer (RAFT) polymerization provides access to a broad variety of biocompatible and functional macromolecules for diverse polymer–drug conjugates. Due to thiocarbonylthio groups at the ends of each growing polymer chain, they can… read more here.
Keywords: polymer drug; raft; end; drug ... See more keywords
Synthesis and Closed-Loop Recycling of Self-Immolative Poly(dithiothreitol)
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecules"
DOI: 10.1021/acs.macromol.0c00861
Abstract: Self-immolative polymers (SIPs) are promising members of the emerging class of recyclable polymers with the ability to end-to-end depolymerize to their monomers. Unfortunately, SIPs are often synth... read more here.
Keywords: recycling self; synthesis closed; loop recycling; self immolative ... See more keywords