Structure-based rational design of self-inhibitory peptides to disrupt the intermolecular interaction between the troponin subunits C and I in neuropathic pain.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.05.004
Abstract: The troponin (Tn) is a ternary complex consisting of three subunits TnC, TnI and TnT; molecular disruption of the Tn complex has been recognized as an attractive strategy against neuropathic pain. Here, a self-inhibitory peptide… read more here.
Keywords: peptide; self inhibitory; based rational; neuropathic pain ... See more keywords
Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.011
Abstract: Animals possess neuronal circuits inducing stress to avoid or cope with threats present in their surroundings, for instance, by promoting behaviors, such as avoidance and escape. However, mechanisms must exist to tightly control responses to… read more here.
Keywords: self inhibitory; galanin; stress; galanin producing ... See more keywords