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   Articles with "self microemulsifying" as a keyword



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Comparisons between a self‐microemulsifying system and lipid nanoparticles of oxyresveratrol on the physicochemical properties and Caco‐2 cell permeability

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recommendations! Published in 2017 at "European Journal of Lipid Science and Technology"

DOI: 10.1002/ejlt.201600053

Abstract: The lipid-based formulations including an oily self-microemulsifying drug delivery system (SMEDDS), solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLC) were developed for the oral delivery of oxyresveratrol (OXYR). Each system was successfully formulated using… read more here.

Keywords: oxyr; self microemulsifying; lipid based; permeability ... See more keywords
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Novel sulforaphane-enabled self-microemulsifying delivery systems (SFN-SMEDDS) of taxanes: Formulation development and in vitro cytotoxicity against breast cancer cells.

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recommendations! Published in 2018 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.11.063

Abstract: Paclitaxel (PTX) and docetaxel (DTX) are highly effective chemotherapeutic agents against breast cancer cells. Existing PTX and DTX formulations, however, contain excipients that result in a multitude of side-effects. The objective of the present study… read more here.

Keywords: self microemulsifying; novel sulforaphane; breast cancer; sulforaphane enabled ... See more keywords
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Development of solidified self-microemulsifying drug delivery systems containing l-tetrahydropalmatine: Design of experiment approach and bioavailability comparison.

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recommendations! Published in 2018 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.12.027

Abstract: The study first aimed to apply a design of experiment (DoE) approach to investigate the influences of excipients on the properties of liquid self-microemulsifying drug delivery system (SMEDDS) and SMEDDS loaded in the pellet (pellet-SMEDDS)… read more here.

Keywords: self microemulsifying; design experiment; pellet smedds; bioavailability ... See more keywords
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Self‐microemulsifying tablets prepared by direct compression for improved resveratrol delivery

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recommendations! Published in 2018 at "International Journal of Pharmaceutics"

DOI: 10.1016/j.ijpharm.2018.06.065

Abstract: ABSTRACT The purpose of this study was to develop self‐microemulsifying (SME‐) tablets to improve resveratrol solubility whilst delivering resveratrol in a preferred tablet dosage form. Resveratrol was dissolved in liquid self‐microemulsifying drug delivery system (SMEDDS)… read more here.

Keywords: resveratrol; self microemulsifying; direct compression; tablets prepared ... See more keywords
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Preparation and evaluation of solid self-microemulsifying drug delivery system of eprosartan mesylate using vegetable oils

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recommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2021.102771

Abstract: Abstract The current work deals with the designing of a solid self-microemulsifying drug delivery system (S-SMEDDS) of eprosartan mesylate (EPM) for improved bioavailability by enhancing the intestinal permeability of EPM. Two L-SMEDDSs containing EPM (OF9… read more here.

Keywords: drug; microemulsifying drug; solid self; drug delivery ... See more keywords
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Self microemulsifying formulation of Lagerstroemia speciosa against chemically induced hepatotoxicity

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recommendations! Published in 2018 at "Journal of Traditional and Complementary Medicine"

DOI: 10.1016/j.jtcme.2017.05.005

Abstract: Self microemulsifying formulation is an approach used for enhancing the bioavailability of poorly soluble molecules due to their lipidic nature and small particle size. The objective of the present study was to evaluate the hepatoprotective… read more here.

Keywords: lagerstroemia speciosa; microemulsifying formulation; self microemulsifying; formulation ... See more keywords
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Lurasidone-β-cyclodextrin complexes: Physicochemical characterization and comparison of their antidepressant, antipsychotic activities against that of self microemulsifying formulation

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recommendations! Published in 2018 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2017.12.042

Abstract: Abstract Lurasidone hydrochloride (LHD) is an atypical antipsychotic drug has poor aqueous solubility and low bioavailability (9–19%). This study describes effect of different methods of complex formation with β-cyclodextrin (BCD) on enhancement of dissolution and… read more here.

Keywords: bcd; self microemulsifying; cyclodextrin; antidepressant antipsychotic ... See more keywords
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Ocular Self-Microemulsifying Drug Delivery System of Prednisolone Improves Therapeutic Effectiveness in the Treatment of Experimental Uveitis

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recommendations! Published in 2019 at "Ocular Immunology and Inflammation"

DOI: 10.1080/09273948.2017.1333622

Abstract: ABSTRACT Purpose: The purpose of this study was to investigate the self-microemulsifying drug delivery systems (SMEDDS) for ophthalmic delivery of Prednisolone (PDN) to treat uveitis. Materials and methods: The pseudo-ternary phase diagrams were developed, and… read more here.

Keywords: self microemulsifying; drug delivery; delivery; drug ... See more keywords
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Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats

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recommendations! Published in 2022 at "Drug Delivery"

DOI: 10.1080/10717544.2022.2086939

Abstract: Abstract Olmesartan medoxomil (OM) is an angiotensin receptor blocker. This study aimed to investigate the effects of OM self-microemulsifying drug delivery system (OMS) in trinitrobenzene sulfonic acid (TNBS)-induced acute colitis in rats. Besides two control… read more here.

Keywords: self microemulsifying; olmesartan medoxomil; drug delivery; microemulsifying drug ... See more keywords
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Supersaturable self-microemulsifying drug delivery system enhances dissolution and bioavailability of telmisartan

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recommendations! Published in 2020 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2020.1834580

Abstract: Abstract To enhance the dissolution and oral bioavailability of telmisartan (TMS), a poorly water-soluble anti-hypertensive drug, a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) was developed. Amorphous alkalinized TMS (AAT) was formulated into a SMEDDS, composed… read more here.

Keywords: self microemulsifying; supersaturable self; drug; bioavailability telmisartan ... See more keywords
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Abstract 2238: Self-microemulsifying drug delivery systems (SMEDDS) containing novel compounds for the chemoprevention of pancreatic cancer

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recommendations! Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-2238

Abstract: Pancreatic cancer (PC) is the fourth leading cause of deaths in the United States, claiming approximately 43,000 lives every year. Existing trends suggest that it will be the second cause of death after lung cancer… read more here.

Keywords: self microemulsifying; chemoprevention; pancreatic cancer; drug ... See more keywords