Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance
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DOI: 10.1002/1873-3468.14347
Abstract: Glycans are carbohydrates that are made by all organisms and covalently conjugated to other biomolecules. Glycans cover the surface of both human cells and pathogens and are fundamental to defining the identity of a cell… read more here.
Keywords: glycans key; nonself discrimination; self nonself; factor self ... See more keywords
Transcriptomic Profiling of the Allorecognition Response to Grafting in the Demosponge Amphimedon queenslandica
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DOI: 10.3390/md15050136
Abstract: Sponges, despite their simple body plan, discriminate between self and nonself with remarkable specificity. Sponge grafting experiments simulate the effects of natural self or nonself contact under laboratory conditions. Here we take a transcriptomic approach… read more here.
Keywords: demosponge amphimedon; amphimedon queenslandica; response; self nonself ... See more keywords
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72416
Abstract: The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alternating cis and trans interactions between… read more here.
Keywords: recognition; neuronal self; clustered protocadherin; specificity ... See more keywords