Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy
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DOI: 10.1002/adma.202411869
Abstract: Glioblastoma (GBM) is the most aggressive subtype of primary brain tumors, which marginally respond to standard chemotherapy due to the blood‐brain barrier (BBB) and the low tumor specificity of the therapeutics. Herein, a double‐layered microneedle… read more here.
Keywords: therapy; protein degradation; self oxygenating; tumor ... See more keywords
A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy.
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DOI: 10.1021/acsnano.5c12847
Abstract: Hypoxia in the tumor microenvironment (TME) severely compromises the effectiveness of sonodynamic therapy (SDT) and disrupts the process of cuproptosis. SDT generates insufficient reactive oxygen species (ROS) under low oxygen levels, while cuproptosis is impeded… read more here.
Keywords: microenvironment responsive; tumor microenvironment; cuproptosis; self oxygenating ... See more keywords