Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection.
Sign Up to like & getrecommendations! Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz057
Abstract: Immune responses against certain viruses are accompanied by autoantibody production although the origin of these infection-associated autoantibodies is unclear. Here we report that murine γ-herpesvirus 68 (MHV68)-induced autoantibodies are derived from polyreactive B cells in… read more here.
Keywords: polyreactive cells; germinal center; cells generated; infection ... See more keywords
Communication management 2.0
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Communication Management"
DOI: 10.1108/jcom-07-2016-0056
Abstract: Purpose The purpose of this paper is to investigate how and why individuals use corporate pages on Facebook with the aim of developing a usage-specific inventory of incentive factors which describe brand page utilization for… read more here.
Keywords: communication management; communication; brand page; behavior ... See more keywords
The 35th annual meeting of the Japanese Society for Neuroimmunology (JSNI)
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Neuroimmunology"
DOI: 10.1111/cen3.12778
Abstract: Objectives : Multiple sclerosis (MS) is associated with the activation of CD4 + T helper (Th) cells by self-antigen from the central nervous system (CNS) to generate pathogenic self-reactive Th cells. Treatment of such autoimmune… read more here.
Keywords: neuroimmunology; self reactive; annual meeting; 35th annual ... See more keywords
Silencing and activating anergic B cells.
Sign Up to like & getrecommendations! Published in 2021 at "Immunological reviews"
DOI: 10.1111/imr.13053
Abstract: Despite the existence of central tolerance mechanisms, including clonal deletion and receptor editing to eliminate self-reactive B cells, moderately self-reactive cells still survive in the periphery (about 20% of peripheral B cells). These cells normally… read more here.
Keywords: self reactive; silencing activating; activating anergic; anergic cells ... See more keywords
The adaptation model of immunity: Is the goal of central tolerance to eliminate defective T cells or self‐reactive T cells?
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13209
Abstract: The self‐non‐self model and the danger model are designed to understand how an immune response is induced. These models are not meant to predict if an immune response may succeed or fail in destroying/controlling its… read more here.
Keywords: self reactive; cells self; central tolerance; defective cells ... See more keywords
Sending B cells back in time
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.366.6461.68-s
Abstract: Lymphocytes B-1 cells are a subset of self-reactive B cells that arise in early life. Precisely how and why the immune system permits the development of self-reactive B cells in neonates remains a mystery. By… read more here.
Keywords: self reactive; cells back; reactive cells; back time ... See more keywords
STAT1 signaling protects self-reactive T cells from control by innate cells during neuroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.148222
Abstract: The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4+ T cells producing IL-17 and GM-CSF, which promote the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis… read more here.
Keywords: reactive cells; protects self; stat1 signaling; self reactive ... See more keywords
Neuropilin‐1 (NRP1) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202215864
Abstract: Pathogenic T helper cells (Th cells) that respond to self‐antigen cannot be easily distinguished from beneficial Th cells. These cells can generate systemic autoimmune disease in response to widely expressed self‐antigens. In this study, we… read more here.
Keywords: disease; neuropilin nrp1; autoimmune disease; systemic autoimmune ... See more keywords
Self-reactive IgE and anti-IgE therapy in autoimmune diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1112917
Abstract: Growing evidence indicates the pathogenic role of autoreactive IgE in autoimmune diseases. Incidence of autoimmune and allergic diseases in the industrialized countries is consistently icreasing, thus leading to concerted efforts to comprehend the regulation of… read more here.
Keywords: reactive ige; autoimmune diseases; ige; self reactive ... See more keywords
Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12030673
Abstract: Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of… read more here.
Keywords: natural compounds; reactive immune; pathology; cancer ... See more keywords
Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.55319
Abstract: Pathogen-specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive… read more here.
Keywords: pathogen specific; versus; antibody responses; receptor ... See more keywords