Feeder cells treated with ethanol can be used to maintain self‐renewal and pluripotency of human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13538
Abstract: Feeder cells play an important role in the culture of human pluripotent stem cells (hPSCs) in vitro. Previously, we used methanol as a fixative to prepare feeder cells for the cultivation of pluripotent stem cells (PSCs),… read more here.
Keywords: pluripotent stem; self renewal; feeder cells; cells treated ... See more keywords
Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1992
Abstract: Lung cancer has the highest mortality rate due to late diagnosis and high incidence of metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self‐renewal capability similar to that of normal stem… read more here.
Keywords: self renewal; lung cancer; cancer; stem ... See more keywords
Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31400
Abstract: Renal cell carcinoma (RCC) is a common and devastating disease characterized by a hypoxic microenvironment, epithelial‐mesenchymal transition and potent resistance to therapy evidencing the presence of cancer stem cells (CSCs). Various CSC markers have been… read more here.
Keywords: rcc; self renewal; resistance; cancer ... See more keywords
Identification, subcellular localization and functional comparison of novel Yap splicing isoforms in mouse embryonic stem cells.
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DOI: 10.1002/iub.2571
Abstract: Hippo signaling pathway is involved in many biological processes including the fate decision of embryonic stem cells (ESCs). Yes-associated protein (Yap) function as a key effector of Hippo pathway, but its role in ESCs is… read more here.
Keywords: isoforms mouse; self renewal; yap; embryonic stem ... See more keywords
Tfcp2l1 safeguards the maintenance of human embryonic stem cell self‐renewal
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DOI: 10.1002/jcp.26483
Abstract: Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed… read more here.
Keywords: maintenance; stem cell; self renewal; embryonic stem ... See more keywords
Noncoding RNAs: Potential players in the self‐renewal of mammalian spermatogonial stem cells
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DOI: 10.1002/mrd.23041
Abstract: Spermatogonial stem cells (SSCs), a unique population of male germ cells with self‐renewal ability, are the foundation for maintenance of spermatogenesis throughout the life of the male. Although many regulatory molecules essential for SSC self‐renewal… read more here.
Keywords: spermatogonial stem; renewal; self renewal; ssc self ... See more keywords
Hhex Regulates Hematopoietic Stem Cell Self‐Renewal and Stress Hematopoiesis via Repression of Cdkn2a
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DOI: 10.1002/stem.2648
Abstract: The hematopoietically expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic progenitors and B‐cells during development. We have recently shown that in adult hematopoiesis, Hhex is dispensable for maintenance of hematopoietic… read more here.
Keywords: hematopoiesis; cdkn2a; self renewal; hematopoietic stem ... See more keywords
Delta‐Like 4 Activates Notch 3 to Regulate Self‐Renewal in Skeletal Muscle Stem Cells
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DOI: 10.1002/stem.2757
Abstract: Notch signaling is essential to maintain skeletal muscle stem cells in quiescence. However, the precise roles of different Notch receptors are incompletely defined. Here, we demonstrate a role for Notch3 (N3) in the self‐renewal of… read more here.
Keywords: skeletal muscle; self renewal; muscle stem; stem ... See more keywords
Myometrial Cells Stimulate Self‐Renewal of Endometrial Mesenchymal Stem‐Like Cells Through WNT5A/β‐Catenin Signaling
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DOI: 10.1002/stem.3070
Abstract: Human endometrium undergoes cycles of proliferation and differentiation throughout the reproductive years of women. The endometrial stem/progenitor cells contribute to this regenerative process. They lie in the basalis layer of the endometrium next to the… read more here.
Keywords: wnt; catenin signaling; myometrial cells; self renewal ... See more keywords
MED31 involved in regulating self-renewal and adipogenesis of human mesenchymal stem cells
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DOI: 10.1007/s11033-018-4241-5
Abstract: Regulation of gene expression is critical for the maintenance of cell state and homeostasis. Aberrant regulation of genes can lead to unwanted cell proliferation or misdirected differentiation. Here we investigate the role of MED31, a… read more here.
Keywords: human mesenchymal; adipogenesis; self renewal; stem ... See more keywords
Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-017-0294-1
Abstract: We develop a three-dimensional multispecies mathematical model to simulate the growth of colon cancer organoids containing stem, progenitor and terminally differentiated cells, as a model of early (prevascular) tumor growth. Stem cells (SCs) secrete short-range… read more here.
Keywords: colon; stem cell; self renewal; cancer ... See more keywords