Cogenerating Synthetic Parts toward a Self-Replicating System.
Sign Up to like & getrecommendations! Published in 2017 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.6b00342
Abstract: To build replicating systems with new functions, the engineering of existing biological machineries requires a sensible strategy. Protein synthesis Using Recombinant Elements (PURE) system consists of the desired components for transcription, translation, aminoacylation and energy… read more here.
Keywords: system; pure system; synthetic parts; cogenerating synthetic ... See more keywords
Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b10796
Abstract: The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood. The recent hypothesis of “RNA-peptide coevolution” suggests that the current… read more here.
Keywords: amino acids; nucleobase; replicating molecules; self ... See more keywords
Therapeutic Applications for Oncolytic Self-Replicating RNA Viruses
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DOI: 10.3390/ijms232415622
Abstract: Self-replicating RNA viruses have become attractive delivery vehicles for therapeutic applications. They are easy to handle, can be rapidly produced in large quantities, and can be delivered as recombinant viral particles, naked or nanoparticle-encapsulated RNA,… read more here.
Keywords: self replicating; replicating rna; therapeutic applications; rna viruses ... See more keywords
Self-Replicating RNA Viruses for Vaccine Development against Infectious Diseases and Cancer
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DOI: 10.3390/vaccines9101187
Abstract: Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-stranded RNA viruses, which have been engineered for recombinant protein expression and vaccine development. Due to the presence of RNA-dependent RNA polymerase activity, subgenomic RNA can replicate… read more here.
Keywords: replicating rna; rna viruses; self replicating; cancer ... See more keywords