Asymmetric autocatalysis of pyrimidyl alkanol and related compounds. Self-replication, amplification of chirality and implication for the origin of biological enantioenriched chirality
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.02.040
Abstract: Abstract We discovered asymmetric autocatalysis in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, where the product 5-pyrimidyl alkanol acts as a highly efficient asymmetric autocatalyst to afford more of itself (Soai reaction). Asymmetric autocatalysis proceeded… read more here.
Keywords: chirality; self replication; asymmetric autocatalysis; autocatalysis ... See more keywords
Energy threshold for chiral symmetry breaking in molecular self-replication
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemistry"
DOI: 10.1038/s41557-019-0321-y
Abstract: The homochirality of biological molecules (right-handed sugars and left-handed amino acids) is a signature of life. Extensive research has been devoted to understanding how enrichment of one enantiomer over the other might have emerged from… read more here.
Keywords: self replication; molecular self; symmetry breaking; energy ... See more keywords
Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918481117
Abstract: Significance Two unresolved problems in Alzheimer’s disease (AD) are its onset and propagation, linked to Aβ peptide aggregation. Fibrils of Aβ42 may grow by monomer addition at their ends. Additionally, through so-called secondary nucleation, fibrils… read more here.
Keywords: secondary nucleation; self replication; alzheimer associated; sides fibrils ... See more keywords
Uncovering the universality of self-replication in protein aggregation and its link to disease
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.06.08.495339
Abstract: Fibrillar protein aggregates are a hallmark of the pathology of a range of human disorders, from prion diseases to dementias. Yet, the same aggregated structures that are formed in disease are also encountered in several… read more here.
Keywords: aggregation; disease; self replication; protein ... See more keywords
Imperative Node Evaluator With Self Replication Mode for Network Intrusion Detection
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Access"
DOI: 10.1109/access.2023.3273904
Abstract: In recent years, network expansion has increased exponentially, making security a pressing issue for modern systems. Monitoring user activity for abnormalities is a useful fraud detection strategy. The ability of a system to efficiently discover… read more here.
Keywords: intrusion; network; self replication; intrusion detection ... See more keywords
Self-Replication of Chiral α-Amino Acids in Strecker-Type Synthesis via Asymmetric Induction and Amplification of Their Own Chiral Intermediate α-Aminonitriles
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20190116
Abstract: Self-replication is one of the essential characteristics of life, therefore, chemical reaction, in which biologically related chiral enantioenriched compounds can promote their own production, is a... read more here.
Keywords: self replication; amino acids; replication chiral; chiral amino ... See more keywords
Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007094
Abstract: The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments… read more here.
Keywords: self replication; horizontal transfer; continued self; loose compartments ... See more keywords