Genome mining and homologous comparison strategy for digging exporters contributing self-resistance in natamycin-producing Streptomyces strains
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10131-7
Abstract: As antibiotics are always toxic to the antibiotic-producing strains themselves, most Streptomyces strains have evolved several self-resistance mechanisms, among which the antibiotic efflux system is understood best and is commonly found. Among the efflux systems,… read more here.
Keywords: natamycin producing; producing streptomyces; streptomyces strains; genome mining ... See more keywords
Discovery of Efrotomycin Congeners and Heterologous Expression-Based Insights into the Self-Resistance Mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00986
Abstract: Four new efrotomycins, A1-A4 (1-4), were isolated from the salt mine-derived Amycolatopsis cihanbeyliensis DSM 45679 and structurally determined. Efrotomycins A3 (3) and A4 (4) feature a tetrahydrofuran ring configured distinctly from known elfamycins. Heterologous expression… read more here.
Keywords: discovery efrotomycin; self resistance; heterologous expression; efrotomycin congeners ... See more keywords
Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00799
Abstract: Capreomycin (CMN) is an important second-line antituberculosis antibiotic isolated from Saccharothrix mutabilis subspecies capreolus. The gene cluster for CMN biosynthesis has been identified and sequenced, wherein the cph gene was annotated as a phosphotransferase likely… read more here.
Keywords: antituberculosis antibiotic; resistance; self resistance; cmn iia ... See more keywords
Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00030
Abstract: Rhizocticins are phosphono-oligopeptide antibiotics that contain a toxic C-terminal ( Z) -l -2-amino-5-phosphono-3-pentenoic acid (APPA) moiety. APPA is an irreversible inhibitor of threonine synthase (ThrC), a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the conversion of… read more here.
Keywords: phosphono oligopeptide; subtilis atcc; appa; atcc 6633 ... See more keywords
Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria† †Electronic supplementary information (ESI) available. CCDC 1831467 and 1831468. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc01325j
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c8sc01325j
Abstract: Mining the genome to harvest from the metabolome: a well-directed search for bioactive natural products unearths the pyxidicyclines from Pyxidicoccus. read more here.
Keywords: resistance guided; genome mining; uncovers new; mining uncovers ... See more keywords
Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01734-20
Abstract: Lugdunin is the first reported nonribosomally synthesized antibiotic from human microbiomes. Its production by the commensal Staphylococcus lugdunensis eliminates the pathogen Staphylococcus aureus from human nasal microbiomes. The cycloheptapeptide lugdunin is the founding member of… read more here.
Keywords: staphylococcus lugdunensis; resistance; self resistance; abc transporters ... See more keywords
The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02826-21
Abstract: Odilorhabdins (ODLs) constitute a novel antibiotic family with promising properties for treating problematic multidrug-resistant Gram-negative bacterial infections. ODLs are 10-mer linear cationic peptides inhibiting bacterial translation by binding to the small subunit of the ribosome.… read more here.
Keywords: cluster; resistance; self resistance; gene ... See more keywords
Mycothiol Peroxidase Activity as a Part of the Self-Resistance Mechanisms against the Antitumor Antibiotic Cosmomycin D
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00493-22
Abstract: Anthracycline compounds are DNA intercalating agents widely used in cancer chemotherapeutic protocols. This work focused on the self-resistance mechanisms developed by the cosmomycin-producing bacterium Streptomyces olindensis. ABSTRACT Antibiotic-producing microorganisms usually require one or more self-resistance… read more here.
Keywords: cosmomycin; mycothiol peroxidase; resistance; self resistance ... See more keywords
LexR Positively Regulates the LexABC Efflux Pump Involved in Self-Resistance to the Antimicrobial Di-N-Oxide Phenazine in Lysobacter antibioticus
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04872-22
Abstract: Antibiotic-producing bacteria exhibit various sophisticated mechanisms for self-protection against their own secondary metabolites. RND efflux pumps that eliminate antibiotics from cells are ubiquitous in Gram-negative bacteria. ABSTRACT Myxin, a di-N-oxide phenazine isolated from the soil… read more here.
Keywords: myxin; resistance; self resistance; pump ... See more keywords
Temperature distribution analysis of carbon fiber reinforced polymer composites during self-resistance electric heating process
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Reinforced Plastics and Composites"
DOI: 10.1177/07316844211073482
Abstract: Self-resistance electric (SRE) heating for carbon fiber reinforced plastics (CFRP) is an alternative out-of-autoclave curing methodology that has high efficiency and low energy consumption. However, thanks to the heating mechanism of inside-out conduction, which is… read more here.
Keywords: resistance electric; temperature; temperature distribution; self resistance ... See more keywords
Penicillin-Binding Proteins, β-Lactamases, and β-Lactamase Inhibitors in β-Lactam-Producing Actinobacteria: Self-Resistance Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105662
Abstract: The human society faces a serious problem due to the widespread resistance to antibiotics in clinical practice. Most antibiotic biosynthesis gene clusters in actinobacteria contain genes for intrinsic self-resistance to the produced antibiotics, and it… read more here.
Keywords: actinobacteria; resistance; self resistance; gene ... See more keywords