Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Nano Research"
DOI: 10.1007/s12274-020-3124-y
Abstract: Multidrug-resistance (MDR) featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the clinic. Compound nanoparticles comprising multiple cytostatics with different mechanisms of action are commonly developed to… read more here.
Keywords: drug; intracellular release; cancer; self targeting ... See more keywords
Genome editing in Streptococcus mutans through self‐targeting CRISPR arrays
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DOI: 10.1111/omi.12247
Abstract: Streptococcus mutans is the primary etiological agent of human dental caries. Its major virulence factors, glucosyltransferases (Gtfs), utilize sucrose to synthesize extracellular polysaccharides (EPS), leading to the formation of dental plaque biofilm. The current study… read more here.
Keywords: crispr; targeting crispr; self targeting; crispr arrays ... See more keywords
Bioinformatics Identification of Anti-CRISPR Loci by Using Homology, Guilt-by-Association, and CRISPR Self-Targeting Spacer Approaches
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DOI: 10.1128/msystems.00455-19
Abstract: As a naturally occurring adaptive immune system, CRISPR-Cas (clustered regularly interspersed short palindromic repeats–CRISPR-associated genes) systems are widely found in bacteria and archaea to defend against viruses. Since 2013, the application of various bacterial CRISPR-Cas… read more here.
Keywords: anti crispr; self targeting; crispr; loci ... See more keywords
Prokaryote autoimmunity in the context of self-targeting by CRISPR-Cas systems
Sign Up to like & getrecommendations! Published in 2020 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s021972002050033x
Abstract: Prokaryote adaptive immunity (CRISPR-Cas systems) can be a threat to its carriers. We analyze the risks of autoimmune reactions related to adaptive immunity in prokaryotes by computational methods. We found important differences between bacteria and… read more here.
Keywords: crispr cas; cas systems; prokaryote autoimmunity; self targeting ... See more keywords