Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100758
Abstract: Exportin 1 (XPO1), also known as chromosome maintenance 1 protein (CRM1), is the main transporter for hundreds of proteins like tumor suppressors, growth regulatory factors, oncoprotein mRNAs and others. Its upregulation leads to the inactivation… read more here.
Keywords: export; selective inhibitor; nuclear export; selinexor selective ... See more keywords
Overview of systemic therapy options in liposarcoma, with a focus on the activity of selinexor, a selective inhibitor of nuclear export in dedifferentiated liposarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/17588359221081073
Abstract: Liposarcoma (LPS) is a common soft tissue sarcoma that encompasses diverse subtypes of well-differentiated/dedifferentiated, myxoid/round cell, and pleomorphic LPS. There is heterogeneity among the various LPS types with regard to prognosis, molecular pathogenesis, and response… read more here.
Keywords: selective inhibitor; overview systemic; selinexor selective; dedifferentiated liposarcoma ... See more keywords
Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13091522
Abstract: Nucleocytoplasmic transport has been found dysregulated in many types of cancer and is often described as a poor prognostic factor. Specifically, Exportin-1 (XPO1) has been found overexpressed in many tumors and has become an attractive… read more here.
Keywords: solid tumors; nuclear export; selinexor selective; non solid ... See more keywords