Sema3A promotes the resolution of cardiac inflammation after myocardial infarction
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0630-5
Abstract: Optimal healing after myocardial infarction requires not only the induction of inflammation, but also its timely resolution. In patients, 30 days post myocardial infarction, circulating monocytes have increased expression of Semaphorin3A (Sema3A) as compared to directly… read more here.
Keywords: resolution; myocardial infarction; inflammation; sema3a ... See more keywords
Expression of semaphorin class 3 is higher in the proliferative phase on the human endometrium
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-018-4719-3
Abstract: PurposeThe semaphorins are related to angiogenesis and cell proliferation depending on the tissue. The purpose of this study was to assess gene expression of class 3 semaphorin (SEMA3A-F) and protein expression of semaphorin 3A (SEMA3A)… read more here.
Keywords: phase; class; endometrium; sema3a ... See more keywords
Semaphorin-3A protects against neointimal hyperplasia after vascular injury
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.12.023
Abstract: BACKGROUND Neointimal hyperplasia is a prominent pathological event during in-stent restenosis. Phenotype switching of vascular smooth muscle cells (VSMCs) from a differentiated/contractile to a dedifferentiated/synthetic phenotype, accompanied by migration and proliferation of VSMCs play an… read more here.
Keywords: hyperplasia vascular; sema3a; vascular injury; neointimal hyperplasia ... See more keywords
Decreased expression of Sema3A, an immune modulator, in blood sample of multiple sclerosis patients.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.02.013
Abstract: Semaphorin 3A (Sema3A) as an immune modulator could participate in the pathogenesis of autoimmune diseases. In the current study, we aimed to investigate Sema3A expression in peripheral blood mononuclear cells (PBMCs) and its serum level… read more here.
Keywords: immune modulator; sema3a; multiple sclerosis; sema3a immune ... See more keywords
Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25290-2
Abstract: Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone… read more here.
Keywords: bone formation; osteosarcoma; sema3a; formation ... See more keywords
Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92375-w
Abstract: Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics to promote nervous… read more here.
Keywords: adult neurons; cone collapse; sema3a; growth cone ... See more keywords
Local treatment with Sema3a could promote the osseointegration of hydroxyapatite coated titanium rod in diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282221075707
Abstract: Recently, semaphorin 3A (Sema3A) has been identified as a critical gene for osteogenic differentiation of mesenchymal stem cells and increases osteoblastic bone formation. However, in current research studies, there is a lack of focus on… read more here.
Keywords: osseointegration; sema3a; treatment sema3a; titanium rod ... See more keywords
Adenovirus-mediated delivery of Sema3A alleviates rheumatoid arthritis in a serum-transfer induced mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19915
Abstract: Rheumatoid arthritis is a chronic autoimmune disease characterized by infiltration of inflammatory cells into the synovium and destruction of cartilage and bone. Macrophages, fibroblast-like synoviocytes (FLS), and osteoclasts are critical cells driving the pathogenesis of… read more here.
Keywords: mediated delivery; adenovirus mediated; sema3a; rheumatoid arthritis ... See more keywords
Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p
Sign Up to like & getrecommendations! Published in 2019 at "Iranian Journal of Medical Sciences"
DOI: 10.30476/ijms.2019.44955
Abstract: Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level. It has been proposed that miRNAs… read more here.
Keywords: expression; blood mononuclear; mir 497; mononuclear cells ... See more keywords
CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
Sign Up to like & getrecommendations! Published in 2023 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-221689
Abstract: BACKGROUND Circular RNA (circRNA) has been found to play an important role in the progression of many diseases, including ischemic stroke. However, the regulatory mechanism of circSEC11A in ischemic stroke progression need to further investigation.… read more here.
Keywords: circsec11a; oxidative stress; sema3a; mir 29a ... See more keywords
Truncated-semaphorin3A is a potential regulatory molecule to restore immune homeostasis in immune-mediated diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1085892
Abstract: Regulatory molecules have recently been recognized for their beneficial effects in the treatment of immune-mediated diseases, rather than using cytotoxic immune-suppressing drugs, which are associated with many unwanted side effects. Semaphorin3A (sema3A), a unique regulatory… read more here.
Keywords: mediated diseases; immune mediated; immune homeostasis; molecule ... See more keywords