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   Articles with "sema3c" as a keyword



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Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family

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recommendations! Published in 2021 at "Human Genetics"

DOI: 10.1007/s00439-021-02289-w

Abstract: Dyslexia is a common heritable developmental disorder involving impaired reading abilities. Its genetic underpinnings are thought to be complex and heterogeneous, involving common and rare genetic variation. Multigenerational families segregating apparent monogenic forms of language-related… read more here.

Keywords: sema3c; variation; whole genome; noncoding variation ... See more keywords
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Genetic inactivation of Semaphorin 3C protects mice from Acute Kidney Injury.

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recommendations! Published in 2022 at "Kidney international"

DOI: 10.1016/j.kint.2021.12.028

Abstract: To guide the development of therapeutic interventions for acute kidney injury, elucidating the deleterious pathways of this global health problem is highly warranted. Emerging evidence has indicated a pivotal role of endothelial dysfunction in the… read more here.

Keywords: semaphorin; kidney injury; acute kidney; injury ... See more keywords
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Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy

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recommendations! Published in 2019 at "Diabetes"

DOI: 10.2337/db18-1172

Abstract: The diabetic cornea exhibits pathological alterations, such as delayed epithelial wound healing and nerve regeneration. We investigated the role of semaphorin (SEMA) 3C in corneal wound healing and reinnervation in normal and diabetic B6 mice.… read more here.

Keywords: sensory nerve; sema3c; regeneration; role ... See more keywords
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SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis

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recommendations! Published in 2019 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2019.01035

Abstract: Introduction: Aberrant activation of Semaphorin3C(SEMA3C) is widespread in human cancers. We aimed to analyze SEMA3C expression in cervical cancer and investigate the role of SEMA3C in cervical cancer and its underlying mechanism, which is important… read more here.

Keywords: sema3c; poor prognosis; associated poor; cervical cancer ... See more keywords
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SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.890154

Abstract: To date, driver genes for pancreatic cancer treatment are difficult to pursue therapeutically. Targeting mutated KRAS, the most renowned driver gene in pancreatic cancer, is an active area of study. We discovered a gene named… read more here.

Keywords: inhibition; sema3c; pancreatic cancer; tumor immune ... See more keywords