Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05761-4
Abstract: Overexpression of semaphorin 4D (SEMA4D), an immune semaphorin, is found in various human malignancies, including colorectal cancer (CRC). In this study, we explored the relationship between silencing SEMA4D expression and 5-fluorouracil (5-FU) response in the… read more here.
Keywords: sema4d; chemosensitivity; colorectal cancer; expression ... See more keywords
Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia
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DOI: 10.1097/hjh.0000000000001808
Abstract: Objective: The signalling of the receptor tyrosine kinase Met is critical in promoting trophoblast cell invasion, and the deficiency in HGF/Met signalling is associated with preeclampsia. The semaphorin family member semaphorin4D (sema4D) and its receptor… read more here.
Keywords: sema4d; invasion; sema4d plexin; met signalling ... See more keywords
Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis.
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DOI: 10.1111/jcmm.17416
Abstract: Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key… read more here.
Keywords: tace mab; tace; osteoclast precursors; anti tace ... See more keywords
Abstract B48: Targeting the semaphorin 4D-plexin B axis to augment FOLFIRINOX in a murine model of pancreatic adenocarcinoma
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DOI: 10.1158/1538-7445.panca19-b48
Abstract: Background: Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality, with dismal 5-year prognosis of 8%, in part due to poor response to available therapies. Thus, new systemic cancer control therapies are in… read more here.
Keywords: sema4d; murine; murine model; plexin ... See more keywords
Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.15172
Abstract: Melanoma is a common skin tumor that causes a high rate of mortality, especially in Europe, North America and Oceania. Immunosuppressants such as anti-PD-1 have been used in the treatment of malignant melanoma, however, nearly… read more here.
Keywords: pi3k akt; signaling pathway; sensitivity; melanoma ... See more keywords