Total glycosides of Paeony shows Neuroprotective effects against Semen Strychni-induced neurotoxicity by recovering secretion of hormones and improving brain energy metabolism
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DOI: 10.1007/s11011-017-0082-5
Abstract: In this study, we investigated the protective effect of total glycosides of paeony against Semen Strychni-induced neurotoxicity and discussed some probably mechanisms. Levels of estrone, estradiol, estriol and growth hormone in male rats’ serum were… read more here.
Keywords: total glycosides; glycosides paeony; neurotoxicity; semen strychni ... See more keywords
Investigation of the detoxification effect of licorice on Semen Strychni-induced acute toxicity in rats using a HPLC-Q-TOF/MS-based metabolomics approach
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DOI: 10.1039/d0ra08568e
Abstract: Semen Strychni, a traditional Chinese medicine (TCM), has been widely used to treat paraplegia, facial nerve palsy and myasthenia gravis. However, its clinical application is greatly limited due to its fatal toxicity. To investigate the… read more here.
Keywords: semen strychni; detoxification effect; acute toxicity; licorice ... See more keywords
Simultaneous Determination of 16-Hydroxystrychnine and Demethylbrucine by LC-MS/MS in Rat Urine and Its Application to Pharmacokinetic Study
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DOI: 10.2174/1872312815666230427122212
Abstract: INTRODUCTION This paper aimed to establish a method to help investigate the combination mechanism of traditional Chinese medicine from the metabolic perspective. BACKGROUND Semen Strychni has been a frequently used herb in clinics for a… read more here.
Keywords: semen strychni; rat urine; study; simultaneous determination ... See more keywords