Semi-mechanistic PK/PD modeling and simulation of irreversible BTK inhibition to support dose selection of tirabrutinib in subjects with RA.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2439
Abstract: Tirabrutinib is an irreversible, small-molecule Bruton's tyrosine kinase (BTK) inhibitor, which was approved in Japan (VELEXBRU® ) to treat B-cell malignancies and is in clinical development for inflammatory diseases. As an application of model-informed drug… read more here.
Keywords: tirabrutinib; semi mechanistic; model; btk ... See more keywords
A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model
Sign Up to like & getrecommendations! Published in 2020 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2020.105322
Abstract: BACKGROUND AND OBJECTIVE The aims of this study are (i) to assess the predictive reliability of the physiologically based software PhysPK versus the well-known population approach software NONMEM for the cited semi-mechanistic PK model, (ii)… read more here.
Keywords: modelling methodology; methodology; semi mechanistic; physiologically based ... See more keywords
Evaluation of semi-mechanistic models to predict soil to grass transfer factor of 137Cs based on long term observations in French pastures.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of environmental radioactivity"
DOI: 10.1016/j.jenvrad.2020.106467
Abstract: The aim of this study was to evaluate and improve the accuracy of the semi-mechanistic models used in regulatory exposure assessment tools, to describe the transfer factors of 137Cs from pasture soils to grass observed… read more here.
Keywords: mechanistic models; term; long term; semi mechanistic ... See more keywords
Application of Semi-Mechanistic Pharmacokinetic and Pharmacodynamic Model in Antimicrobial Resistance
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DOI: 10.3390/pharmaceutics14020246
Abstract: Antimicrobial resistance is a major public health issue. The pharmacokinetic/pharmacodynamic (PK/PD) model is an essential tool to optimize dosage regimens and alleviate the emergence of resistance. The semi-mechanistic PK/PD model is a mathematical quantitative tool… read more here.
Keywords: pharmacodynamic model; pharmacokinetic pharmacodynamic; semi mechanistic; resistance ... See more keywords