Semi-mechanistic PK/PD modeling and simulation of irreversible BTK inhibition to support dose selection of tirabrutinib in subjects with RA.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2439
Abstract: Tirabrutinib is an irreversible, small-molecule Bruton's tyrosine kinase (BTK) inhibitor, which was approved in Japan (VELEXBRU® ) to treat B-cell malignancies and is in clinical development for inflammatory diseases. As an application of model-informed drug… read more here.
Keywords: tirabrutinib; semi mechanistic; model; btk ... See more keywords
A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model
Sign Up to like & getrecommendations! Published in 2020 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2020.105322
Abstract: BACKGROUND AND OBJECTIVE The aims of this study are (i) to assess the predictive reliability of the physiologically based software PhysPK versus the well-known population approach software NONMEM for the cited semi-mechanistic PK model, (ii)… read more here.
Keywords: modelling methodology; methodology; semi mechanistic; physiologically based ... See more keywords
Evaluation of semi-mechanistic models to predict soil to grass transfer factor of 137Cs based on long term observations in French pastures.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of environmental radioactivity"
DOI: 10.1016/j.jenvrad.2020.106467
Abstract: The aim of this study was to evaluate and improve the accuracy of the semi-mechanistic models used in regulatory exposure assessment tools, to describe the transfer factors of 137Cs from pasture soils to grass observed… read more here.
Keywords: mechanistic models; term; long term; semi mechanistic ... See more keywords
A semi-mechanistic pharmacokinetic/pharmacodynamic model for quantifying phage-antibiotic synergy against Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2025 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2025.2520963
Abstract: ABSTRACT Background Multidrug‐resistant (MDR) Pseudomonas aeruginosa is among the top three pathogens urgently needing new treatments. Phage therapy offers an alternative to antibiotics by auto-dosing and by targeting bacteria that are resistant to conventional antibiotics,… read more here.
Keywords: phage; semi mechanistic; pseudomonas aeruginosa; model ... See more keywords
Phenotype‐Specific Semi‐Mechanistic Modelling of Florfenicol Time‐Kill Curves in G. Parasuis Compared to Other Respiratory Pathogens
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Veterinary Pharmacology and Therapeutics"
DOI: 10.1111/jvp.13500
Abstract: This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time‐kill assays and semi‐mechanistic PD modeling were… read more here.
Keywords: time kill; semi mechanistic; average free; respiratory ... See more keywords
Application of Semi-Mechanistic Pharmacokinetic and Pharmacodynamic Model in Antimicrobial Resistance
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DOI: 10.3390/pharmaceutics14020246
Abstract: Antimicrobial resistance is a major public health issue. The pharmacokinetic/pharmacodynamic (PK/PD) model is an essential tool to optimize dosage regimens and alleviate the emergence of resistance. The semi-mechanistic PK/PD model is a mathematical quantitative tool… read more here.
Keywords: pharmacodynamic model; pharmacokinetic pharmacodynamic; semi mechanistic; resistance ... See more keywords