Semi-synthesis of disulfide-linked branched tri-ubiquitin mimics
Sign Up to like & getrecommendations! Published in 2018 at "Science China Chemistry"
DOI: 10.1007/s11426-017-9189-6
Abstract: Ubiquitin (Ub) chain isopeptide bond mimics are useful molecules for biochemical and biophysical studies. Herein, we report the semi-synthesis of the disulfide-linked K11/K48-branched tri-Ub (Ub311/48(S–S)), the first example of an isopeptide mimic for the branched… read more here.
Keywords: semi synthesis; synthesis disulfide; synthesis; disulfide linked ... See more keywords
Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103917
Abstract: 7-O-galloyltricetiflavan (GTF), a natural flavonoid, is known to exert anti-oxidation and neuroprotective activity, which are related to the prevention of Alzheimer's disease (AD). In this study, three series of GTF hybrids have been designed, synthesized… read more here.
Keywords: semi synthesis; alzheimer disease; treatment; synthesis biological ... See more keywords
Efficient ortho-formylation in vitamin E series, application to the semi-synthesis of natural 5- and 7-formyl-δ-tocotrienols revealing an unprecedented 5-bromo-7-formyl exchange
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.10.039
Abstract: Semi-synthesis of 5- and 7-formyltocopherols and tocotrienols has been developed by ortho-formylation of C-5 or C-7-unsubstituted vitamin E derivatives (14 examples) up to 90% yield, through heating in the presence of respectively 10-10-15 equivalents of… read more here.
Keywords: bromo; bromo formyl; ortho formylation; semi synthesis ... See more keywords
Efficient semi-synthesis of ubiquitin-7-amino-4-methylcoumarin
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DOI: 10.1016/j.tet.2018.05.081
Abstract: Abstract Ubiquitin (Ub)-based probe Ub-7-amino-4-methylcoumarin is widely used to detect deubiquitinase (DUB) enzymatic activity, but its current synthesis procedures are cumbersome. In this work, we reported a new highly efficient semi-synthetic strategy to prepare Ub-AMC… read more here.
Keywords: semi synthesis; ubiquitin; efficient semi; amino methylcoumarin ... See more keywords
Semi-Synthesis of Chloroxaloterpin A and B and Their Antifungal Activity against Botrytis cinerea.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01242
Abstract: Chloroxaloterpin A (1) and B (2) are two diterpenoids with potent inhibitory activities against spore germination of Botrytis cinerea, which were identified from Streptomyces sp. SN194 as minor products previously. In order to overcome the… read more here.
Keywords: chloroxaloterpin; synthesis chloroxaloterpin; semi synthesis; botrytis cinerea ... See more keywords
Semi-synthesis and HPLC analysis of (bacterio)chlorophyllides possessing a propionic acid residue at the C17-position
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s1088424618500347
Abstract: Various chlorophyll and bacteriochlorophyll derivatives possessing a magnesium or zinc atom at the central position and a free carboxylic acid group at the C172-position, also known as (bacterio)ch... read more here.
Keywords: hplc analysis; bacterio; semi synthesis; analysis bacterio ... See more keywords