Hexahydrocannabinol and closely related semi-synthetic cannabinoids: A comprehensive review.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3519
Abstract: Since the early 2000s, there has been a turmoil on the global illicit cannabinoid market. Parallel to legislative changes in some jurisdictions regarding herbal cannabis, unregulated and cheap synthetic cannabinoids with astonishing structural diversity have… read more here.
Keywords: pharmacology; hemp; semi synthetic; hexahydrocannabinol closely ... See more keywords
Hydrophilic interaction liquid chromatography-mass spectrometry as a new tool for the characterization of intact semi-synthetic glycoproteins.
Sign Up to like & getrecommendations! Published in 2017 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.05.020
Abstract: Improved methods for detailed characterization of complex glycoproteins are required in the growing sector of biopharmaceuticals. Hydrophilic interaction liquid chromatography (HILIC) coupled to high resolution (HR) time-of-flight mass spectrometric (TOF-MS) detection was examined for the… read more here.
Keywords: characterization intact; interaction liquid; semi synthetic; hydrophilic interaction ... See more keywords
A Semi-Synthetic Organism that Stores and Retrieves Increased Genetic Information
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24659
Abstract: Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central… read more here.
Keywords: information; semi synthetic; base; genetic information ... See more keywords
Investigating the role of the strong field ligands in [FeFe] hydrogenase: spectroscopic and functional characterization of a semi-synthetic mono-cyanide active site
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc02271k
Abstract: Artificial maturation of hydrogenases provides a path towards generating new semi-synthetic enzymes with novel catalytic properties. Here enzymes featuring a synthetic asymmetric mono-cyanide cofactor have been prepared using two different hydrogenase scaffolds. Their structure and… read more here.
Keywords: hydrogenase; semi synthetic; cyanide; mono cyanide ... See more keywords
Cytotoxic potential of dihydrochalcones from Eriosema glomeratum and their semi-synthetic derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2111563
Abstract: In the search of cytotoxic dihydrochalcones, this investigation led to the isolation of seven compounds (1-7) from Eriosema glomeratum and the preparation of eight derivatives (8-15). The cytotoxicity of samples was evaluated against lung (A549),… read more here.
Keywords: dihydrochalcones eriosema; potential dihydrochalcones; glomeratum semi; semi synthetic ... See more keywords
Analysing two‐dimensional effects in central loop transient electromagnetic sounding data using a semi‐synthetic tipper approach
Sign Up to like & getrecommendations! Published in 2018 at "Geophysical Prospecting"
DOI: 10.1111/1365-2478.12520
Abstract: We present a simple and feasible approach to analyse and identify two-dimensional effects in central loop transient electromagnetic sounding data and the correspondingly derived quasi two-dimensional conductivity models. The proposed strategy is particularly useful in… read more here.
Keywords: semi synthetic; tipper; two dimensional; transient electromagnetic ... See more keywords
The Effect of Antitumor Antibiotic Olivomycin A and Its New Semi-synthetic Derivative Olivamide on the Activity of Murine DNA Methyltransferase Dnmt3a
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297919010085
Abstract: Olivomycin A is a highly active antitumor drug that belongs to the family of aureolic acid antibiotics. The antitumor effect of olivomycin A is related to its ability to bind to the DNA minor groove… read more here.
Keywords: dna; semi synthetic; dna methyltransferase; antitumor ... See more keywords
Semi-synthetic cinnamodial analogues: Structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito Aedes aegypti
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008073
Abstract: The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the… read more here.
Keywords: aedes aegypti; cinnamodial analogues; synthetic cinnamodial; semi synthetic ... See more keywords
Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20180182
Abstract: In this work, a search for antimicrobial agents against multi-drug resistant (MDR) bacteria was undertaken. It involved two natural diterpenes of different basic skeletons, named ent-kaurenoic acid and ent-pimaradienoic acid, that were used as precursors… read more here.
Keywords: semi synthetic; clinically isolated; antimicrobial potential; ent ... See more keywords
Bergenin of Peltophorum dubium (Fabaceae) Roots and Its Bioactive Semi‑Synthetic Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20200141
Abstract: This work describes the isolation of pure bergenin from Peltophorum dubium roots with good yields and its further derivatization through Williamson synthesis. The alkyl derivatives of the bergenin were identified by nuclear magnetic resonance and… read more here.
Keywords: synthetic derivatives; bergenin; semi synthetic; peltophorum dubium ... See more keywords
Natural products and their (semi-)synthetic forms in treatment of migraine: History and current status.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190125155947
Abstract: BACKGROUND Migraine may be described as a headache with moderate to extreme pain that is often accompanied by incapacitating neurological symptoms. It is estimated that 12% of the world population suffers from migraine. Although a… read more here.
Keywords: treatment migraine; natural products; semi synthetic; treatment ... See more keywords