Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6445-1_4
Abstract: Saponins are triterpene glycoside natural products that exhibit many different biological properties, including activation and modulation of the immune system, and have therefore attracted significant interest as immunological adjuvants for use in vaccines. QS-21 is… read more here.
Keywords: saponin immunoadjuvant; biology; analogues saponin; semisynthesis analogues ... See more keywords
Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00434
Abstract: Hypothemycin, an epoxide derivative of (5Z)-7-oxozeaenol, was used in the semisynthesis of a series of C8-C9 diol derivatives, with many inhibiting TAK1 at submicromolar concentrations. A step-economical approach was chosen, whereby nonselective reactions functionalized the… read more here.
Keywords: semisynthesis; hypothemycin analogues; hypothemycin; targeting diol ... See more keywords