Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21.
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DOI: 10.1007/978-1-4939-6445-1_4
Abstract: Saponins are triterpene glycoside natural products that exhibit many different biological properties, including activation and modulation of the immune system, and have therefore attracted significant interest as immunological adjuvants for use in vaccines. QS-21 is… read more here.
Keywords: saponin immunoadjuvant; biology; analogues saponin; semisynthesis analogues ... See more keywords
The H-cluster of [FeFe] Hydrogenases: Its Enzymatic Synthesis and Parallel Inorganic Semisynthesis
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DOI: 10.1021/acs.accounts.4c00231
Abstract: Conspectus Nature’s prototypical hydrogen-forming catalysts—hydrogenases—have attracted much attention because they catalyze hydrogen evolution at near zero overpotential and ambient conditions. Beyond any possible applications in the energy sphere, the hydrogenases feature complicated active sites, which… read more here.
Keywords: fefe hydrogenases; cluster; biosynthesis; synthesis ... See more keywords
Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol.
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DOI: 10.1021/acs.jnatprod.2c00434
Abstract: Hypothemycin, an epoxide derivative of (5Z)-7-oxozeaenol, was used in the semisynthesis of a series of C8-C9 diol derivatives, with many inhibiting TAK1 at submicromolar concentrations. A step-economical approach was chosen, whereby nonselective reactions functionalized the… read more here.
Keywords: semisynthesis; hypothemycin analogues; hypothemycin; targeting diol ... See more keywords
Identification of Granatane Alkaloids from Duboisia myoporoides (Solanaceae) using Molecular Networking and Semisynthesis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.4c00304
Abstract: The Solanaceae plant family contains at least 98 genera and over 2700 species. The Duboisia genus stands out for its ability to produce pyridine and tropane alkaloids, which are relatively poorly characterized at the phytochemical… read more here.
Keywords: granatane; identification granatane; semisynthesis; molecular networking ... See more keywords